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Uncategorized Published - 17 June, 2019    By - Dr Clemens
Pupillary Pain Index Changes After a Standardized Bolus of Alfentanil Under Sevoflurane Anesthesia

AUTHORS: Sabourdin, Nada, MD et al Anesthesia & Analgesia: March 2019 – Volume 128 – Issue 3 – p 467–474 BACKGROUND: The pupillary pain index (PPI) is a novel pupillometric index, designed to assess intraoperative analgesia. It is based on the evaluation of the pupillary response to electrical stimuli of increasing intensity. It ranges from 1 […]

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Uncategorized Published - 17 June, 2019    By - Dr Clemens
Evidence Basis for Regional Anesthesia in Ambulatory Anterior Cruciate Ligament Reconstruction

AUTHORS: Yung, Eric M., BHSc, MD (Cand) et al Anesthesia & Analgesia: March 2019 – Volume 128 – Issue 3 – p 426–437 BACKGROUND: Local infiltration analgesia offers effective postoperative analgesia after knee arthroplasty, but the role of its counterpart, local instillation analgesia (LIA), in anterior cruciate ligament reconstruction (ACLR) is unclear. This systematic review and […]

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Uncategorized Published - 17 June, 2019    By - Dr Clemens
Andexanet for Major Hemorrhage in Patients on Factor Xa Inhibitors

Authors: Connolly SJ et al. N Engl J Med 2019 Feb 7 An uncontrolled study shows rapid efficacy in reducing elevated anti-FXa inhibitor levels. The anticoagulant activity of oral direct factor Xa (FXa) inhibitors and low-molecular-weight heparins such as enoxaparin can be reversed by andexanet, a modified, recombinant inactive form of FXa. Andexanet was recently approved […]

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Uncategorized Published - 14 June, 2019    By - Dr Clemens
Changes in Whole Brain Dynamics and Connectivity Patterns during Sevoflurane- and Propofol-induced Unconsciousness Identified by Functional Magnetic Resonance Imaging

Authors: Daniel Golkowski, M.D. et al Anesthesiology 6 2019, Vol.130, 898-911. doi:10.1097/ALN.0000000000002704 Editor’s Perspective:What We Already Know about This Topic: The extent to which alterations within specific brain networks impairs communication among networks remains unknown What This Article Tells Us That Is New: In a volunteer functional magnetic resonance study, general anesthesia reduced activity within and […]

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Uncategorized Published - 14 June, 2019    By - Dr Clemens
Dynamic Cortical Connectivity during General Anesthesia in Surgical Patients

Authors: Phillip E. Vlisides, M.D. et al Anesthesiology 6 2019, Vol.130, 885-897. Editor’s Perspective:What We Already Know about This Topic: Animal data, along with recent human observations (in this issue of Anesthesiology*), suggest that cortical oscillations and connectivity shift dynamically during what appears to be stable general anesthesia Clinical evidence in the perioperative setting to support […]

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