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Uncategorized Published - 3 July, 2025    By - Dr Clemens
A pharmacist-partnered opioid tapering service before total hip or knee arthroplasty

Authors: Young, Sophie A. et al Background Currently, no literature on patients’ experiences with opioid tapering before elective surgery has been published. Recent evidence indicates tapering opioids before total hip or knee arthroplasty improves post-surgical outcomes. This study qualitatively analyzed consultation sessions of patients receiving a pharmacist-partnered opioid tapering service before total hip or knee […]

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Uncategorized Published - 3 July, 2025    By - Dr Clemens
Ketamine-induced sustained modulation of GABAA receptor function in mouse hippocampal neurons following anesthesia

Authors: Wang, Dian-Shi M.D., Ph.D et al Anesthesiology ():10.1097/ALN.0000000000005595, June 09, 2025. Background: Excess function of GABAA receptors that generate a tonic inhibitory conductance contributes to postanesthetic cognitive impairment. Ketamine may have postoperative cognition-sparing properties; however, whether it reduces excess GABAA receptor function is unknown. This study investigated whether ketamine prevents a sustained anesthetic-triggered increase in GABAA receptor function in […]

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Uncategorized Published - 2 July, 2025    By - Dr Clemens
Perioperative Nitric Oxide Conditioning Reduces Acute Kidney Injury in Cardiac Surgery Patients with Chronic Kidney Disease (the DEFENDER Trial)

Authors: Kamenshchikov, Nikolay O. M.D. et al  Anesthesiology ():10.1097/ALN.0000000000005494, June 12, 2025. Background: Postoperative acute kidney injury (AKI) is a significant concern for cardiac surgery patients with chronic kidney disease (CKD). Effective pharmacologic interventions to mitigate these risks are urgently needed. This study aimed to evaluate the efficacy and safety of perioperative NO administration in preventing […]

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Uncategorized Published - 2 July, 2025    By - Dr Clemens
Effects of Sedative Doses of Propofol, Dexmedetomidine, and Fentanyl on Memory and Pain in Healthy Young Adults

Authors: Vogt, Keith M. M.D., Ph.D. et al Anesthesiology ():10.1097/ALN.0000000000005489, June 13, 2025. Background: Anesthetic agents are well known for their effects on memory and pain; however, previous studies quantifying anesthetic modulation of memory have not included experimental noxious stimulation. This study used functional magnetic resonance imaging to determine how low doses of propofol, dexmedetomidine, and […]

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Uncategorized Published - 2 July, 2025    By - Dr Clemens
Analgesic benefits of motor-sparing fascial plane blocks in comparison to periarticular local infiltration analgesia for total hip arthroplasty

Authors: Hussain, Nasir MD et al Anesthesiology ():10.1097/ALN.0000000000005607, June 09, 2025 Background: Periarticular local infiltration analgesia has become an important mainstay of multimodal analgesia following elective total hip arthroplasty (THA). However, the role of novel motor-sparing fascial plane blocks – with or without periarticular local infiltration analgesia – has not been fully elucidated for patients undergoing […]

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