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AUTHORS: Turan, Alparslan MD et al Anesthesia & Analgesia: September 2020 – Volume 131 – Issue 3 – p 822-829 BACKGROUND: Uncontrolled pain after noncardiac surgery activates the sympathetic nervous system, which causes tachycardia, hypertension, and increased cardiac contractility—all of which may increase myocardial oxygen demand. We therefore determined whether time-weighted average pain scores over […]
Read MoreAUTHORS: Hunsberger, Joann B. MD, MS et al Anesthesia & Analgesia: September 2020 – Volume 131 – Issue 3 – p 866-875 BACKGROUND: The epidemic of nonmedical use of prescription opioids (NMUPOs) has been fueled in part by the availability of leftover, legitimately prescribed opioids. In children, outpatient urological procedures are among the most common […]
Read MoreAUTHORS: i, Jiafu MD et al Anesthesia & Analgesia: September 2020 – Volume 131 – Issue 3 – p 935-942 BACKGROUND: The misuse of opioids stems, in part, from inadequate knowledge of molecular interactions between opioids and opioid receptors. It is still unclear why some opioids are far more addictive than others. The κ-opioid receptor […]
Read MoreDG Alert A study published in the Journal of Clinical Endocrinology & Metabolism shows a 13.1% rate of thyroid dysfunction among patients with predominantly mild-to-moderate coronavirus disease 2019 (COVID-19). “There may be a direct effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on thyroid function, potentially leading to exacerbation of pre-existing autoimmune thyroid disease. Low free […]
Read MoreDG Alerts A study published in Science Advances reports on the ability of baricitinib, a JAK/STAT pathway inhibitor, to inhibit viral entry and reduce inflammatory markers in coronavirus disease 2019 (COVID-19) patients, reducing mortality risk by 71% among patients with moderate-severe COVID-19 pneumonia. In addition, the study shows that baricitinib prevents the type-1 interferon (IFN) mediated increase […]
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