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Authors: Hao Li, M.D. et al Anesthesiology December 2020, Vol. 133, 1244–1259. Background Acid-sensing ion channel 3 (ASIC3) upregulation has been reported in dorsal root ganglion neurons after incision and contributes to postoperative nociception. This study hypothesized that upregulation of ASIC3 in incised tissues is induced by nerve growth factor through the phosphoinositide 3–kinase/protein kinase […]
Read MoreAuthor: Avery Hurt Practical Pain Management As more states have legalized marijuana for medical and/or recreational purposes – especially after the state measure ballots, cannabis use has become more common across the United States with the CDC reporting that 22.2 million Americans use the substance each month.1 Despite a plethora of sociological and health-based studies […]
Read MoreAuthors: Jasper Kamp, Pharm.D. et al Anesthesiology December 2020, Vol. 133, 1192–1213. Background Several models describing the pharmacokinetics of ketamine are published with differences in model structure and complexity. A systematic review of the literature was performed, as well as a meta-analysis of pharmacokinetic data and construction of a pharmacokinetic model from raw data sets to […]
Read MoreCleveland Clinic If your little one needs surgery, odds are good you have many questions — and concerns. Is it really OK to put kids under general anesthesia? “Anesthesia is very safe. Parents and families shouldn’t be scared,” says pediatric anesthesiologist Julie Niezgoda, MD. Still, it helps to understand what’s involved so you can minimize the […]
Read MoreAuthor: Christina Frangou General Surgery News In patients who underwent abdominal surgery, IV acetaminophen did not reduce the duration of postoperative hypoxemia compared with placebo in a randomized, double-blind trial. In the trial, IV acetaminophen did not significantly reduce postoperative pain, and it reduced opioid consumption by 14%, or 4 mg per day, an amount […]
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