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Uncategorized Published - 19 March, 2021    By - Dr Clemens
An Observational Study of the Pharmacokinetics of Surgeon-Performed Intercostal Nerve Blockade With Liposomal Bupivacaine for Posterior-Lateral Thoracotomy Analgesia

AUTHORS: Manson, William C. MD et al Anesthesia & Analgesia: December 2020 – Volume 131 – Issue 6 – p 1843-1849 BACKGROUND:  Intercostal nerve blocks with liposomal bupivacaine are commonly used for thoracic surgery pain management. However, dose scheduling is difficult because the pharmacokinetics of a single-dose intercostal injection of liposomal bupivacaine has never been […]

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Uncategorized Published - 19 March, 2021    By - Dr Clemens
An Implementation-Effectiveness Study of a Perioperative Delirium Prevention Initiative for Older Adults

AUTHORS: Donovan, Anne L. MD et al Anesthesia & Analgesia: December 2020 – Volume 131 – Issue 6 – p 1911-1922 BACKGROUND:  Postoperative delirium is a common and serious problem for older adults. To better align local practices with delirium prevention consensus guidelines, we implemented a 5-component intervention followed by a quality improvement (QI) project […]

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Uncategorized Published - 19 March, 2021    By - Dr Clemens
Derivation, Validation, Sustained Performance, and Clinical Impact of an Electronic Medical Record–Based Perioperative Delirium Risk Stratification Tool

AUTHORS: Whitlock, Elizabeth L. MD, MSc et al Anesthesia & Analgesia: December 2020 – Volume 131 – Issue 6 – p 1901-1910 BACKGROUND:  Postoperative delirium is an important problem for surgical inpatients and was the target of a multidisciplinary quality improvement project at our institution. We developed and tested a semiautomated delirium risk stratification instrument, […]

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Uncategorized Published - 19 March, 2021    By - Dr Clemens
Hemodynamic Parameters in the Assessment of Fluid Status in a Porcine Hemorrhage and Resuscitation Model

Authors: Eric S. Wise, M.D. et al Anesthesiology April 2021, Vol. 134, 607–616. Background Measuring fluid status during intraoperative hemorrhage is challenging, but detection and quantification of fluid overload is far more difficult. Using a porcine model of hemorrhage and over-resuscitation, it is hypothesized that centrally obtained hemodynamic parameters will predict volume status more accurately […]

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Uncategorized Published - 18 March, 2021    By - Dr Clemens
A Lower Tidal Volume Regimen during One-lung Ventilation for Lung Resection Surgery Is Not Associated with Reduced Postoperative Pulmonary Complications

Authors: Douglas A. Colquhoun, M.B.Ch.B., M.Sc., M.P.H. et al  Anesthesiology April 2021, Vol. 134, 562–576. Background Protective ventilation may improve outcomes after major surgery. However, in the context of one-lung ventilation, such a strategy is incompletely defined. The authors hypothesized that a putative one-lung protective ventilation regimen would be independently associated with decreased odds of pulmonary […]

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