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Authors: Qiliang Jiang, M.D. et al Anesthesiology May 2021, Vol. 134, 709–721. Background Whether supplemental oxygen worsens long-term mortality remains unclear, with contradictory trial results. The authors therefore tested the hypothesis that supplemental oxygen (80% vs. 30%) increases the hazard for long-term mortality. Methods The authors conducted a post hoc analysis of a large multiple crossover cluster trial in […]
Read MoreDG Journal Club AUTHORS: Sin Yin Lim, Jamie L Miller et al. Pharmacotherapy. 2021 Feb 19 INTRODUCTION Fentanyl pharmacokinetic and pharmacodynamic data are limited in mechanically ventilated children. This study aims to assess the fentanyl pharmacokinetics (PK), the sedation outcome, and the development of tolerance in children receiving fentanyl continuous infusion. METHODS This study included […]
Read MoreAuthor: Michael Walter Cardiovascular Business Clinicians may not necessarily need to assess a patient’s surgical risk when determining if they are a suitable candidate for transcatheter aortic valve replacement (TAVR), according to a new study published in Current Problems in Cardiology. Instead, that time could be spent focusing on other important considerations such as the patient’s […]
Read MoreAUTHORS: Yi Yuan, Yanan Song et al. BMJ Open. 2021 Feb 12; 11(2): INTRODUCTION Postoperative delirium (POD) is a common neurological complication after hip fracture surgery and is associated with high morbidity and mortality in elderly patients. Although the specific mechanism of POD remains unclear, circadian rhythm disruptions have recently drawn increased attention. To date, […]
Read MoreDG Journal club AUTHORS: Yi Chen, Lili Zou et al. Pharmacotherapy. 2021 Feb 14 BACKGROUND Prophylactic norepinephrine infusion effectively lowers the incidence of postspinal anesthesia hypotension. The optimal prophylactic dose of norepinephrine remains undefined. The purpose of this study was to investigate the optimal prophylactic dose of norepinephrine to prevent postspinal anesthesia hypotension in patients […]
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