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Uncategorized Published - 27 September, 2021    By - Dr Clemens
Apelin-13 Reverses Bupivacaine-Induced Cardiotoxicity via the Adenosine Monophosphate–Activated Protein Kinase Pathway

AUTHORS: Ye, Yingchao MD et al Anesthesia & Analgesia: October 2021 – Volume 133 – Issue 4 – p 1048-1059 BACKGROUND:  Cardiotoxicity can be induced by the commonly used amide local anesthetic, bupivacaine. Bupivacaine can inhibit protein kinase B (AKT) phosphorylation and activated adenosine monophosphate–activated protein kinase alpha (AMPKα). It can decouple mitochondrial oxidative phosphorylation […]

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Uncategorized Published - 27 September, 2021    By - Dr Clemens
Effects of different remifentanil target concentrations on MAC BAR of sevoflurane in patients with liver dysfunction under carbon dioxide pneumoperitoneum stimulus

DG Journal Club AUTHORS: Ping-Ping Jiang, Yan-Xia Guo et al. J Clin Pharm Ther. 2021 Sep 12 WHAT IS KNOWN AND OBJECTIVE Remifentanil can effectively decrease the sevoflurane concentration to block sympathetic adrenergic response to CO 2 pneumoperitoneum stimulus,and liver dysfunction will significantly reduce the MAC BAR (minimum alveolar concentration for blocking adrenergic response) of […]

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Uncategorized Published - 27 September, 2021    By - Dr Clemens
Volatile anesthetic agents for life-threatening pediatric asthma

DG Journal Club AUTHORS: Alicia Lew, John M Morrison et al. Paediatr Anaesth. 2021 Sep 12 BACKGROUND Volatile anesthetic agents are described as rescue therapy for children invasively ventilated for critical asthma. Yet, data are currently limited to case series. AIMS Using the Virtual Pediatric Systems database, we assessed children admitted to a pediatric intensive […]

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Uncategorized Published - 24 September, 2021    By - Dr Clemens
Associations Between Preoperative Biomarkers and Cardiac Surgery–Associated Acute Kidney Injury in Elderly Patients

AUTHORS: Verwijmeren, Lisa MD, PhD et al Anesthesia & Analgesia: September 2021 – Volume 133 – Issue 3 – p 570-577 BACKGROUND:  Acute kidney injury (AKI) is associated with mortality after cardiac surgery. Novel risk factors may improve identification of patients at risk for renal injury. The authors evaluated the association between preoperative biomarkers that reflect […]

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Uncategorized Published - 24 September, 2021    By - Dr Clemens
Drug Labeling in the Perioperative Environment: Issues that May Contribute to Medication Errors

Authors: Elizabeth Rebello, R.Ph, MD, FASA, CPPS et al  ASA Monitor September 2021, Vol. 85, 40–41. Medication error is the most common type of medical error in the United States, injuring approximately 1.3-1.5 million people and accounting for 251,000 preventable deaths per year (asamonitor.pub/2SF59mC; Preventing Medication Errors. 2007; BMJ 2016;353:i2139). Although medication errors in anesthesia are difficult […]

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