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Uncategorized Published - 1 October, 2021    By - Dr Clemens
Pharmacologic Management of Intensive Care Unit Delirium

AUTHORS: Boncyk, Christina S. MD et al Anesthesia & Analgesia: September 2021 – Volume 133 – Issue 3 – p 713-722 BACKGROUND: Pharmacologic agents are frequently utilized for management of intensive care unit (ICU) delirium, yet prescribing patterns and impact of medication choices on patient outcomes are poorly described. We sought to describe prescribing practices for […]

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Uncategorized Published - 1 October, 2021    By - Dr Clemens
P2Y1 Purinergic Receptor Contributes to Remifentanil-Induced Cold Hyperalgesia via Transient Receptor Potential Melastatin 8–Dependent Regulation of N-methyl-d-aspartate Receptor Phosphorylation in Dorsal Root Ganglion

AUTHORS: Su, Lin MD, PhD et al Anesthesia & Analgesia: September 2021 – Volume 133 – Issue 3 – p 794-810 BACKGROUND:  Remifentanil can induce postinfusion cold hyperalgesia. N-methyl-d-aspartate receptor (NMDAR) activation and upregulation of transient receptor potential melastatin 8 (TRPM8) membrane trafficking in dorsal root ganglion (DRG) are critical to cold hyperalgesia derived from neuropathic pain, […]

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Uncategorized Published - 1 October, 2021    By - Dr Clemens
Activation of Orexinergic Neurons Inhibits the Anesthetic Effect of Desflurane on Consciousness State via Paraventricular Thalamic Nucleus in Rats

AUTHORS: Zhao, Shiyi MD et al  Anesthesia & Analgesia: September 2021 – Volume 133 – Issue 3 – p 781-793 BACKGROUND:  Orexin, a neuropeptide derived from the perifornical area of the hypothalamus (PeFLH), promotes the recovery of propofol, isoflurane, and sevoflurane anesthesias, without influencing the induction time. However, whether the orexinergic system also plays a similar […]

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Uncategorized Published - 30 September, 2021    By - Dr Clemens
Midazolam Premedication Immediately Before Surgery Is Not Associated With Early Postoperative Delirium

AUTHORS: Wang, Man-Ling MD et al  Anesthesia & Analgesia: September 2021 – Volume 133 – Issue 3 – p 765-771 BACKGROUND:  Postoperative delirium is common among older surgical patients and may be associated with anesthetic management during the perioperative period. The aim of this study is to assess whether intravenous midazolam, a short-acting benzodiazepine used frequently […]

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Uncategorized Published - 30 September, 2021    By - Dr Clemens
Point-of-Care Lung Ultrasound Pattern in Healthy Parturients: Prevalence of Pulmonary Interstitial Syndrome Following Vaginal Delivery, Elective and Unplanned Intrapartum Cesarean Delivery

AUTHORS: Macias, Paul MD, MS, RD et al Anesthesia & Analgesia: September 2021 – Volume 133 – Issue 3 – p 739-746 BACKGROUND:  Pregnancy-related cardiovascular physiologic changes increase the likelihood of pulmonary edema, with the risk of fluid extravasating into the pulmonary interstitium being potentially at a maximum during the early postpartum period. Data on the […]

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