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Uncategorized Published - 30 June, 2021    By - Dr Clemens
FDA approves first oral blood thinner for pediatric patients

Author: Michael Walter Cardiovascular Business The U.S. Food and Drug Administration has announced multiple new approvals for dabigatran etexilate—and it made a little bit of history along the way. Dabigatran etexilate, sold by Boehringer Ingelheim under the name Pradaxa, is now approved as a treatment option for venous thromboembolism in patients between the ages of […]

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Uncategorized Published - 30 June, 2021    By - Dr Clemens
Routine Postsurgical Anesthesia Visit to Improve 30-Day Morbidity and Mortality

DG Journal Club AUTHORS: Wolfgang F F A Buhre, Christa Boer et al. Ann Surg. 2021 May 24 OBJECTIVE To study the impact of a standardized postoperative anesthesia visit on 30-day mortality in medium to high-risk elective surgical patients. BACKGROUND Postoperative complications are the leading cause of perioperative morbidity and mortality. While modified early warning […]

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Uncategorized Published - 30 June, 2021    By - Dr Clemens
Quantitative Pupillometry as a Predictor of Pediatric Postoperative Opioid–Induced Respiratory Depression

AUTHORS: Packiasabapathy, Senthil MD et al Anesthesia & Analgesia: May 2021 BACKGROUND: Safe postoperative pain relief with opioids is an unmet critical medical need in children. There is a lack of objective, noninvasive bedside tool to assess central nervous system (CNS) effects of intraoperative opioids. Proactive identification of children at risk for postoperative respiratory depression (RD) […]

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Uncategorized Published - 30 June, 2021    By - Dr Clemens
Relationship Between Intraoperative and Preoperative Ambulatory Nighttime Heart Rates

AUTHORS: Kouz, Karim MD et al Anesthesia & Analgesia: June 2021 BACKGROUND: It remains unknown what constitutes physiologically relevant intraoperative bradycardia. Intraoperative bradycardia is usually defined using absolute heart rate thresholds, ignoring preoperative baseline heart rates. In contrast, we considered defining intraoperative bradycardia relative to preoperative ambulatory nighttime heart rate. Specifically, we hypothesized that the individual […]

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Uncategorized Published - 30 June, 2021    By - Dr Clemens
Driving Pressure–Guided Individualized Positive End-Expiratory Pressure in Abdominal Surgery

AUTHORS: Zhang, Chengmi MD, PhD et al Anesthesia & Analgesia: June 2021 BACKGROUND: The optimal positive end-expiratory pressure (PEEP) to prevent postoperative pulmonary complications (PPCs) remains unclear. Recent evidence showed that driving pressure was closely related to PPCs. In this study, we tested the hypothesis that an individualized PEEP guided by minimum driving pressure during abdominal […]

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