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Uncategorized Published - 14 July, 2021    By - Dr Clemens
Interleukin-6 Is an Early Plasma Marker of Severe Postoperative Complications in Thoracic Surgery

AUTHORS: Neff, Thomas A. MD et al Anesthesia & Analgesia: June 16, 2021 BACKGROUND: Postoperative complications in surgery are a significant burden, not only for the patients but also economically. While several predicting factors have already been identified, it is still not well known if increased levels of inflammatory markers in the immediate perioperative phase correlate […]

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Uncategorized Published - 14 July, 2021    By - Dr Clemens
Driving Pressure–Guided Individualized Positive End-Expiratory Pressure in Abdominal Surgery

AUTHORS: Zhang, Chengmi MD, PhD et al Anesthesia & Analgesia: June 11, 2021 BACKGROUND: The optimal positive end-expiratory pressure (PEEP) to prevent postoperative pulmonary complications (PPCs) remains unclear. Recent evidence showed that driving pressure was closely related to PPCs. In this study, we tested the hypothesis that an individualized PEEP guided by minimum driving pressure during […]

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Uncategorized Published - 14 July, 2021    By - Dr Clemens
Effectiveness of Perioperative Opioid Educational Initiatives

AUTHORS: Zorrilla-Vaca, Andres MD et al Anesthesia & Analgesia: June 11, 2021 BACKGROUND: Opioids are the most commonly prescribed analgesics in the United States. Current guidelines have proposed education initiatives to reduce the risk of chronic opioid consumption, yet there is lack of efficacy data on such interventions. Our study evaluates the impact of perioperative opioid […]

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Uncategorized Published - 14 July, 2021    By - Dr Clemens
Effects of the ABCB1 c.3435C>T (rs1045642) Polymorphism on Heat Pain Perception in Opioid-Free Adults With Chronic Pain

AUTHORS: Hooten, W. Michael MD et al Anesthesia & Analgesia: June 21, 2021 BACKGROUND: The adenosine triphosphate-binding cassette, subfamily B, member 1 gene (ABCB1) encodes P-glycoprotein (P-gp) that influences the intracellular transport of solutes including endogenous opioid peptides. The primary objective of this study was to determine the effects of the ABCB1 polymorphism c.3435C>T (rs10454642) on heat pain […]

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Uncategorized Published - 14 July, 2021    By - Dr Clemens
Relationship Between Intraoperative and Preoperative Ambulatory Nighttime Heart Rates

AUTHORS: Kouz, Karim MD et al Anesthesia & Analgesia: June 9, 2021 – BACKGROUND: It remains unknown what constitutes physiologically relevant intraoperative bradycardia. Intraoperative bradycardia is usually defined using absolute heart rate thresholds, ignoring preoperative baseline heart rates. In contrast, we considered defining intraoperative bradycardia relative to preoperative ambulatory nighttime heart rate. Specifically, we hypothesized that […]

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