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Uncategorized Published - 13 December, 2021    By - Dr Clemens
Hydroxyethyl Starch for Fluid Management in Patients Undergoing Major Abdominal Surgery

AUTHORS: Pensier, Joris MD et al Anesthesia & Analgesia: November 2021 BACKGROUND: In critically ill patients, warnings about a risk of death and acute kidney injury (AKI) with hydroxyethyl starch (HES) solutions have been raised. However, HES solutions may yet have a role to play in major abdominal surgery. This meta-analysis and trial sequential analysis (TSA) […]

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Uncategorized Published - 13 December, 2021    By - Dr Clemens
Low-Concentration Norepinephrine Infusion for Major Surgery

AUTHORS: Aykanat, Verna M. FANZCA, MBBS, BMedSci (Hons) et al Anesthesia & Analgesia: December 2021 BACKGROUND: Prevention of hypotension during the intra- and postoperative period is an important goal. Peripheral administration of low-concentration norepinephrine may be a safe and effective strategy to reduce the risk of hypotension. METHODS: We conducted a 2-center, randomized pilot feasibility trial, […]

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Uncategorized Published - 13 December, 2021    By - Dr Clemens
Extracellular Vesicles From Women With Severe Preeclampsia Impair Vascular Endothelial Function

AUTHORS: Murugesan, Saravanakumar PhD Anesthesia & Analgesia: December 2021 BACKGROUND: Preeclampsia (PE) manifesting as hypertension and organ injury is mediated by vascular dysfunction. In biological fluids, extracellular vesicles (EVs) containing microRNA (miRNA), protein, and other cargo released from the placenta may serve as carriers to propagate injury, altering the functional phenotype of endothelial cells. PE has […]

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Uncategorized Published - 10 December, 2021    By - Dr Clemens
Hydroxyethyl Starch for Fluid Management in Patients Undergoing Major Abdominal Surgery

AUTHORS: Pensier, Joris MD et al  Anesthesia & Analgesia: November 2021 BACKGROUND: In critically ill patients, warnings about a risk of death and acute kidney injury (AKI) with hydroxyethyl starch (HES) solutions have been raised. However, HES solutions may yet have a role to play in major abdominal surgery. This meta-analysis and trial sequential analysis (TSA) […]

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Uncategorized Published - 10 December, 2021    By - Dr Clemens
The Relation Between Mean Arterial Pressure and Cardiac Index in Major Abdominal Surgery Patients

AUTHORS: Kouz, Karim MD et al Anesthesia & Analgesia: December 2021 BACKGROUND: Cardiac output is an important hemodynamic variable and determines oxygen delivery. In contrast to blood pressure, cardiac output is rarely measured even in high-risk surgical patients, suggesting that clinicians consider blood pressure to be a reasonable indicator of systemic blood flow. However, the relationship […]

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