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Authors: Michele Carella et al. Source: European Journal of Anaesthesiology 42(12):1043-1045, December 2025. DOI: 10.1097/EJA.0000000000002269 SummaryThis editorial commentary by Carella et al. reviews a randomized controlled trial by Yousef et al. that rigorously re-examined a longstanding but poorly supported practice in regional anesthesia—the admixture of amide-type local anesthetics (LAs) such as lidocaine and ropivacaine. The […]
Read MoreAuthor: Carla Cantor Medscape BMJ Evidence-Based Medicine. Tramadol, a commonly prescribed opioid often viewed as a safer option for chronic pain, provided limited pain relief while increasing the risk for serious side effects, results of a new analysis showed. In a systematic review and meta-analysis, investigators found that tramadol offered clinically insignificant pain relief, while […]
Read MoreAuthors: Nasr, Viviane G. et al. Anesthesiology October 2025 | DOI: 10.1097/ALN.0000000000005783 This multicenter registry study characterized the incidence and predictors of intraoperative cardiac events in pediatric patients with congenital heart disease (CHD) undergoing noncardiac procedures. While previous studies focused primarily on mortality, this analysis—drawing from seven U.S. centers—specifically examined real-time intraoperative hemodynamic and cardiac […]
Read MoreAuthors: Vollert, Jan et al. Anesthesiology October 2025 | DOI: 10.1097/ALN.0000000000005792 This large multicenter European study established reference values for the minimal clinically important difference (MCID) in postoperative pain and physical function using patient-reported outcome measures (PROMs). The MCID defines the smallest change in a score that patients perceive as meaningful—crucial for interpreting clinical trial […]
Read MoreAuthor: Megan Brooks Medscape JAMA Psychiatry. Psychological therapy that changes an individual’s beliefs about pain can provide lasting relief for chronic back pain (CBP), long-term follow-up results of a randomized controlled trial showed. More than half of those who received the brain-focused pain reprocessing therapy (PRT) reported being nearly or completely pain-free 5 years later, […]
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