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Uncategorized Published - 1 October, 2021    By - Dr Clemens
Incidence, Mortality, and Characteristics of 18 Pediatric Perioperative Cardiac Arrests

AUTHORS: Jansen, Gerrit Dr med et al Anesthesia & Analgesia: September 2021 – Volume 133 – Issue 3 – p 747-754 BACKGROUND:  Recently, a very low incidence of 3 per 10,000 and a mortality of 30% were reported for pediatric perioperative cardiac arrest (POCA). However, high-risk patients, namely children already anesthetized on the intensive care unit […]

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Uncategorized Published - 1 October, 2021    By - Dr Clemens
REsidual Neuromuscular Block Prediction Score Versus Train-of-Four Ratio and Respiratory Outcomes

AUTHORS: Patrocínio, Maria D. MD et al Anesthesia & Analgesia: September 2021 – Volume 133 – Issue 3 – p 610-619 BACKGROUND:  Residual neuromuscular blockade is associated with an increased incidence of postoperative respiratory complications. The REsidual neuromuscular block Prediction Score (REPS) identifies patients at high risk for residual neuromuscular blockade after surgery. METHODS: A total […]

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Uncategorized Published - 1 October, 2021    By - Dr Clemens
Pharmacologic Management of Intensive Care Unit Delirium

AUTHORS: Boncyk, Christina S. MD et al Anesthesia & Analgesia: September 2021 – Volume 133 – Issue 3 – p 713-722 BACKGROUND: Pharmacologic agents are frequently utilized for management of intensive care unit (ICU) delirium, yet prescribing patterns and impact of medication choices on patient outcomes are poorly described. We sought to describe prescribing practices for […]

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Uncategorized Published - 1 October, 2021    By - Dr Clemens
P2Y1 Purinergic Receptor Contributes to Remifentanil-Induced Cold Hyperalgesia via Transient Receptor Potential Melastatin 8–Dependent Regulation of N-methyl-d-aspartate Receptor Phosphorylation in Dorsal Root Ganglion

AUTHORS: Su, Lin MD, PhD et al Anesthesia & Analgesia: September 2021 – Volume 133 – Issue 3 – p 794-810 BACKGROUND:  Remifentanil can induce postinfusion cold hyperalgesia. N-methyl-d-aspartate receptor (NMDAR) activation and upregulation of transient receptor potential melastatin 8 (TRPM8) membrane trafficking in dorsal root ganglion (DRG) are critical to cold hyperalgesia derived from neuropathic pain, […]

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Uncategorized Published - 1 October, 2021    By - Dr Clemens
Activation of Orexinergic Neurons Inhibits the Anesthetic Effect of Desflurane on Consciousness State via Paraventricular Thalamic Nucleus in Rats

AUTHORS: Zhao, Shiyi MD et al  Anesthesia & Analgesia: September 2021 – Volume 133 – Issue 3 – p 781-793 BACKGROUND:  Orexin, a neuropeptide derived from the perifornical area of the hypothalamus (PeFLH), promotes the recovery of propofol, isoflurane, and sevoflurane anesthesias, without influencing the induction time. However, whether the orexinergic system also plays a similar […]

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