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Uncategorized Published - 20 October, 2021    By - Dr Clemens
Apelin-13 Reverses Bupivacaine-Induced Cardiotoxicity via the Adenosine Monophosphate–Activated Protein Kinase Pathway

AUTHORS: Ye, Yingchao MD et al Anesthesia & Analgesia: October 2021 – Volume 133 – Issue 4 – p 1048-1059 BACKGROUND:  Cardiotoxicity can be induced by the commonly used amide local anesthetic, bupivacaine. Bupivacaine can inhibit protein kinase B (AKT) phosphorylation and activated adenosine monophosphate–activated protein kinase alpha (AMPKα). It can decouple mitochondrial oxidative phosphorylation and […]

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Uncategorized Published - 19 October, 2021    By - Dr Clemens
Immediate Effects of a Continuous Peripheral Nerve Block on Postamputation Phantom and Residual Limb Pain

AUTHORS: Ilfeld, Brian M. MD, MS et al Anesthesia & Analgesia: October 2021 – Volume 133 – Issue 4 – p 1019-1027 BACKGROUND:  We recently reported that a 6-day continuous peripheral nerve block reduced established postamputation phantom pain 3 weeks after treatment ended. However, the immediate effects of perineural infusion (secondary outcomes) have yet to be […]

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Uncategorized Published - 19 October, 2021    By - Dr Clemens
Association Between Intraoperative Remifentanil Dosage and Postoperative Opioid Consumption in Adolescent Idiopathic Spine Surgery

AUTHORS: Lo, Calvin MD, MSc et al Anesthesia & Analgesia: October 2021 – Volume 133 – Issue 4 – p 984-990 BACKGROUND:  Adolescent idiopathic scoliosis (AIS) surgery is associated with significant postoperative pain. Remifentanil is a short-acting opioid that is often used as a component of total intravenous anesthesia. Remifentanil has been implicated in acute opioid […]

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Uncategorized Published - 19 October, 2021    By - Dr Clemens
Quantitative Pupillometry as a Predictor of Pediatric Postoperative Opioid–Induced Respiratory Depression

AUTHORS: Packiasabapathy, Senthil MD et al Anesthesia & Analgesia: October 2021 – Volume 133 – Issue 4 – p 991-999 BACKGROUND:  Safe postoperative pain relief with opioids is an unmet critical medical need in children. There is a lack of objective, noninvasive bedside tool to assess central nervous system (CNS) effects of intraoperative opioids. Proactive identification […]

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Uncategorized Published - 19 October, 2021    By - Dr Clemens
Effect of Permissive Mild Hypercapnia on Cerebral Vasoreactivity in Infants

AUTHORS: Schopfer, Leonore MMSc et al Anesthesia & Analgesia: October 2021 – Volume 133 – Issue 4 – p 976-983 BACKGROUND:  Mechanical ventilation interferes with cerebral perfusion via changes in intrathoracic pressure and/or as a consequence of alterations in CO2. Cerebral vascular vasoreactivity is dependent on CO2, and hypocapnia can potentially lead to vasoconstriction and subsequent […]

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