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Uncategorized Published - 12 November, 2025    By - Dr Clemens
General anesthesia and systemic hyperosmolality modulate lumbar intrathecal drug distribution in female rats

Authors: Persson, Niklas Daniel Åke et al. Anesthesiology October 2025 | DOI: 10.1097/ALN.0000000000005794 This preclinical imaging study investigated how anesthesia type and systemic hyperosmolality affect the central nervous system (CNS) distribution of intrathecally administered drugs. The researchers examined the pharmacokinetics of a high–molecular weight spinal tracer (technetium-99m–labeled human serum albumin nanocolloid, 66.5 kDa) in female […]

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Uncategorized Published - 12 November, 2025    By - Dr Clemens
Cannabis Extract Relieves Chronic Low Back Pain: Phase 3 Study

Edited by Melissa Warburg Medscape A recent phase 3 study of more than 800 adults, published in Nature, revealed encouraging results for a cannabis extract in treating chronic low back pain, offering new hope for patients seeking nonopioid relief. VER-01, a full-spectrum Cannabis sativa extract, provided sustained pain reduction while also improving sleep quality and physical function, and without requiring […]

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Uncategorized Published - 11 November, 2025    By - Dr Clemens
Neonatal outcomes with regional versus general anesthesia for cesarean delivery

Authors: Langer, Sarah et al. Anesthesiology October 2025 | DOI: 10.1097/ALN.0000000000005785 This meta-analysis of randomized controlled trials compared neonatal outcomes following cesarean delivery performed under regional anesthesia (spinal, epidural, or combined spinal-epidural) versus general anesthesia. Although regional techniques are widely preferred for maternal safety and recovery, their comparative effect on neonatal well-being has remained uncertain. […]

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Uncategorized Published - 11 November, 2025    By - Dr Clemens
Mode of Anesthesia for Patients with Placenta Accreta Spectrum undergoing Cesarean Hysterectomy

Authors: Padilla, Andrew et al. Anesthesiology October 2025 | DOI: 10.1097/ALN.0000000000005788 This multicenter retrospective cohort study examined anesthetic practices for cesarean hysterectomy in patients with placenta accreta spectrum (PAS) using data from the Multicenter Perioperative Outcomes Group (MPOG) database. Placenta accreta, increta, and percreta represent progressively invasive forms of abnormal placentation associated with massive hemorrhage […]

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Uncategorized Published - 11 November, 2025    By - Dr Clemens
A Randomized Controlled Trial of Intraoperative Ketamine for Acute Postsurgical Pain after Breast Cancer Surgery

Authors: Wilson, Jenna et al. Anesthesiology October 2025 | DOI: 10.1097/ALN.0000000000005649 This prospective randomized controlled trial evaluated whether intraoperative ketamine reduces acute postsurgical pain in women undergoing breast cancer surgery, while also examining whether baseline temporal summation of pain (a measure of central sensitization) influences ketamine’s efficacy. A total of 225 patients were randomized to […]

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