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Uncategorized Published - 23 May, 2022    By - Dr Clemens
Midazolam at Low Nanomolar Concentrations Affects Long-term Potentiation and Synaptic Transmission Predominantly via the α1–γ-Aminobutyric Acid Type A Receptor Subunit in Mice

Authors: Xènia Puig-Bosch, M.Sc. et al Anesthesiology June 2022, Vol. 136, 954–969. Background Midazolam amplifies synaptic inhibition via different γ-aminobutyric acid type A (GABAA) receptor subtypes defined by the presence of α1-, α2-, α3-, or α5-subunits in the channel complex. Midazolam blocks long-term potentiation and produces postoperative amnesia. The aims of this study were to identify the GABAA receptor […]

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Uncategorized Published - 20 May, 2022    By - Dr Clemens
Facial Pressure Ulcers: Unsightly Complication of Prone Positioning

Authors: Eliane Varga, M.D. et al  Anesthesiology May 2022, Vol. 136, 827–828. The image depicts a 67-yr-old man who had significant periorbital skin injury after 5 h of prone spine surgery using a foam headrest with standard taping of eyes. The patient underwent facial laser skin resurfacing 2 months before the event. Facial pressure ulcers are a […]

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Uncategorized Published - 20 May, 2022    By - Dr Clemens
Fascial Plane Blocks in Cardiothoracic Surgery

Author: Dibash Kumar Das, PhD ASA Monitor March 2021, Vol. 85, 34–35. Cardiothoracic surgeries are associated with significant pain. Optimal analgesia is a vital part of enhanced recovery after surgery strategies intended to improve patients’ perioperative experience and outcomes. Traditionally, analgesia in these types of surgeries has depended on large doses of I.V. opioids (Anesth Analg […]

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Uncategorized Published - 20 May, 2022    By - Dr Clemens
Recent U.S. Food and Drug Administration Labeling Changes for Hydroxyethyl Starch Products Due to Concerns about Mortality, Kidney Injury, and Excess Bleeding

Authors: Laurence Landow, M.D. et al  Anesthesiology May 2022, Vol. 136, 868–870. To the Editor: The U.S. Food and Drug Administration (Silver Spring, Maryland) is requiring safety labeling changes to the prescribing information for hydroxyethyl starch products to warn about the risk of mortality, acute kidney injury (AKI), and coagulopathy in all patient populations. The changes […]

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Uncategorized Published - 20 May, 2022    By - Dr Clemens
SEE Question

ASA Monitor June 2021, Vol. 85, 21. A recent observational cohort study compared the annualized rate of major adverse cardiac events (MACE) in patients with abnormal exercise electrocardiograms (+ECG) but normal stress echocardiograms (–Echo) to patients with normal exercise ECGs (–ECG) and normal stress echocardiograms (–Echo). According to this study, which of the following statements is […]

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