Author: Dr Clemens

Uncategorized Published - 3 March, 2021    By - Dr Clemens
Clinical Effectiveness of Liposomal Bupivacaine Administered by Infiltration or Peripheral Nerve Block to Treat Postoperative Pain

Authors: Brian M. Ilfeld, M.D., M.S. et al Anesthesiology February 2021, Vol. 134, 283–344. The authors provide a comprehensive summary of all randomized, controlled trials (n = 76) involving the clinical administration of liposomal bupivacaine (Exparel; Pacira Pharmaceuticals, USA) to control postoperative pain that are currently published. When infiltrated surgically and compared with unencapsulated bupivacaine or […]

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Uncategorized Published - 2 March, 2021    By - Dr Clemens
Application of a High-Flow Nasal Cannula for Prevention of Postextubation Atelectasis in Children Undergoing Surgery

AUTHORS: Lee, Ji-Hyun MD, PhD et al Anesthesia & Analgesia: November 2020 BACKGROUND: General anesthesia-induced atelectasis is common, and persistent postoperative atelectasis is associated with pulmonary complications. We aimed to evaluate the preventive effects of a high-flow nasal cannula (HFNC) on postoperative atelectasis and respiratory complications in infants and small children. METHODS: In this prospective […]

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Uncategorized Published - 2 March, 2021    By - Dr Clemens
Parental Psychosocial Factors Moderate Opioid Administration Following Children’s Surgery

AUTHORS: Kain, Alexandra S. BA et al Anesthesia & Analgesia: November 2020 BACKGROUND: This investigation aimed to examine the impact of parental psychosocial variables on the administration of opioids to young children experiencing postoperative pain. METHODS: Participants in this longitudinal analysis were children ages 2–12 undergoing tonsillectomy with or without adenoidectomy and their parents. Parents […]

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Uncategorized Published - 2 March, 2021    By - Dr Clemens
Rifampin Reduces the Plasma Concentrations of Oral and Intravenous Hydromorphone in Healthy Volunteers

AUTHORS: Lohela, Terhi J. MD, PhD et al Anesthesia & Analgesia: November 2020 BACKGROUND: Several opioids are metabolized by the inducible cytochrome P450 (CYP) 3A isozymes. Coadministration with strong inducers of drug metabolism, such as rifampin, can dramatically reduce systemic exposure to these opioids. As the CYP metabolism of hydromorphone is of minor importance, we […]

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Uncategorized Published - 2 March, 2021    By - Dr Clemens
Intraoperative Hypotension Is Associated With Adverse Clinical Outcomes After Noncardiac Surgery

AUTHORS: Gregory, Anne MD, MSc, FRCPC et al Anesthesia & Analgesia: November 2020 BACKGROUND: Intraoperative hypotension (IOH) occurs frequently during surgery and may be associated with organ ischemia; however, few multicenter studies report data regarding its associations with adverse postoperative outcomes across varying hemodynamic thresholds. Additionally, no study has evaluated the association between IOH exposure […]

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Uncategorized Published - 2 March, 2021    By - Dr Clemens
Logistical Considerations and Clinical Outcomes Associated with Converting Operating Rooms into an Intensive Care Unit during the Covid-19 Pandemic in a New York City Hospital

AUTHORS: Mittel, Aaron M. MD et al Anesthesia & Analgesia: October 2020 Background: Covid-19 emerged as a public health crisis that disrupted normal patterns of health care in the New York City metropolitan area. In preparation for a large influx of critically ill patients, operating rooms (ORs) at NewYork-Presbyterian Hospital/Columbia University Irving Medical Center (NYP-Columbia) […]

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Uncategorized Published - 1 March, 2021    By - Dr Clemens
Preoperative Point-of-Care Assessment of Left Ventricular Systolic Dysfunction With Transthoracic Echocardiography

AUTHORS: Stenberg, Ylva MD et al Anesthesia & Analgesia: March 2021 – Volume 132 – Issue 3 – p 717-725 BACKGROUND:  Left ventricular (LV) systolic dysfunction is an acknowledged perioperative risk factor and should be identified before surgery. Conventional echocardiographic assessment of LV ejection fraction (LVEF) obtained by biplane LV volumes is the gold standard […]

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Uncategorized Published - 1 March, 2021    By - Dr Clemens
Postoperative Neurocognitive Disorders After Closed-Loop Versus Manual Target Controlled-Infusion of Propofol and Remifentanil in Patients Undergoing Elective Major Noncardiac Surgery

AUTHORS: Mahr, Nicolas MD et al * Anesthesia & Analgesia: November 2020 BACKGROUND: The aim of the study was to investigate whether closed-loop compared to manual bispectral index (BIS)–guided target-controlled infusion of propofol and remifentanil could decrease the incidence of postoperative neurocognitive disorders after elective major noncardiac surgery. METHODS: Patients aged >50 admitted for elective […]

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Uncategorized Published - 1 March, 2021    By - Dr Clemens
Recommendations for Endotracheal Intubation of COVID-19 Patients

Author: Orser, Beverley A. MD, PhD Anesthesia & Analgesia: May 2020 – Volume 130 – Issue 5 – p 1109-1110 Health care workers are committed to learning from each other to optimize the management of coronavirus disease 2019 (COVID-19) patients. The World Health Organization (WHO) and the International Committee on Taxonomy of Viruses recently called […]

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Uncategorized Published - 1 March, 2021    By - Dr Clemens
Effect of high-risk obstructive sleep apnea on clinical outcomes in adults with COVID-19

DG Alerts Coronavirus disease 2019 (COVID-19) patients with modified high-risk obstructive sleep apnea (mHR-OSA) had poorer clinical outcomes than those with modified low-risk obstructive sleep apnea (mLR-OSA) independent of age, sex and comorbidities, according to a study published in Annals of the American Thoracic Society. “To our best knowledge, there were no prospective reports published about […]

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