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DG Journal Club AUTHORS: Ersin Koksal, Hakan Aygun et al. Int J Clin Pract. 2021 Jun 12 BACKGROUND Quadratus lumborum blocks (QLB) are relatively novel regional anesthesia techniques, and the efficacy of all three types of QLB for postoperative analgesia in cesarean delivery (CD) has been demonstrated in separate studies. The aim of the present […]
Read MoreDG Journal Club AUTHORS: Andrea P Haren, Shrijit Nair et al. Adv Ther. 2021 Jun 5 With the increasing prevalence of obesity in the population, anaesthetists must confidently manage both the pathophysiological and technical challenges presented in bariatric and non-bariatric surgery. The intraoperative period represents an important opportunity to optimise and mitigate risk. However, there […]
Read MoreDG Journal Club AUTHORS: Senthil Packiasabapathy, Xue Zhang et al. Anesth Analg. 2021 May 24 BACKGROUND Safe postoperative pain relief with opioids is an unmet critical medical need in children. There is a lack of objective, noninvasive bedside tool to assess central nervous system (CNS) effects of intraoperative opioids. Proactive identification of children at risk […]
Read MoreAUTHORS: Kouz, Karim MD et al Anesthesia & Analgesia: June 2021 BACKGROUND: It remains unknown what constitutes physiologically relevant intraoperative bradycardia. Intraoperative bradycardia is usually defined using absolute heart rate thresholds, ignoring preoperative baseline heart rates. In contrast, we considered defining intraoperative bradycardia relative to preoperative ambulatory nighttime heart rate. Specifically, we hypothesized that the […]
Read MoreDG Journal Club AUTHORS: Ben Maudlin, Stephen B Gibson et al. Intern Med J. 2021 Jun 6 INTRODUCTION Chronic non-malignant pain is a disabling condition that results in a reduction in function and quality of life when inadequately managed. Sub-lingual ketamine has been shown to be efficacious for use in chronic pain. Despite its use […]
Read MoreDG Journal Club AUTHORS: Uzeyir Cimen, Atakan Yilmaz et al. Int J Clin Pract. 2021 Jun 12 OBJECTIVES Sore throat is one of the most prevalent causes of emergency visits. The chief purpose of this clinical report is to investigate the effectiveness of intravenous (IV) dexketoprofen and paracetamol drugs relative to each other in relieving […]
Read MoreDG Journal Club AUTHORS: Jana Semrau, Christian Hentschke et al. BMC Musculoskelet Disord. 2021 May 29; 22(1): 500 BACKGROUND The long-term effects of behavioural medical rehabilitation (BMR), as a type of multidisciplinary rehabilitation, in the treatment of chronic non-specific low back pain (CLBP) have been shown. However, the specific effects of behavioural exercise therapy (BET) […]
Read MoreDG Journal Club AUTHORS: Tatsuo Horiuchi, Tomonori Takazawa et al. J Med Case Rep. 2021 Jun 5; 15(1): 313 BACKGROUND Sugammadex is a synthetic γ-cyclodextrin derivative designed to selectively bind to steroidal neuromuscular blocking agents and reverse their effects. Although many cases of sugammadex-induced anaphylaxis have been reported, few studies have investigated the underlying mechanism. […]
Read MoreAUTHORS: Hooten, W. Michael MD et al Anesthesia & Analgesia: June 2021 BACKGROUND: The adenosine triphosphate-binding cassette, subfamily B, member 1 gene (ABCB1) encodes P-glycoprotein (P-gp) that influences the intracellular transport of solutes including endogenous opioid peptides. The primary objective of this study was to determine the effects of the ABCB1 polymorphism c.3435C>T (rs10454642) on heat pain (HP) […]
Read MoreAuthor: Michael Walter Cardiovascular Business The U.S. Food and Drug Administration has announced multiple new approvals for dabigatran etexilate—and it made a little bit of history along the way. Dabigatran etexilate, sold by Boehringer Ingelheim under the name Pradaxa, is now approved as a treatment option for venous thromboembolism in patients between the ages of […]
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