Author: Dr Clemens

Uncategorized Published - 13 July, 2021    By - Dr Clemens
The Facilitatory Effects of Adjuvant Pharmaceutics to Prolong the Duration of Local Anesthetic for Peripheral Nerve Block

AUTHORS: Xuan, Chengluan MD, PhD et al Anesthesia & Analgesia: June 21, 2021 BACKGROUND: Peripheral nerve block (PNB) with perineural local anesthetic is used for anesthesia or analgesia with many benefits. To extend these benefits, various adjuvant drugs have been used to prolong the duration of analgesia. We aimed to evaluate the effectiveness of various adjuvants […]

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Uncategorized Published - 13 July, 2021    By - Dr Clemens
Intrathecal 2-Chloroprocaine 3% Versus Hyperbaric Bupivacaine 0.75% for Cervical Cerclage

AUTHORS: Lee, Allison MD, MS et al Anesthesia & Analgesia: June 21, 2021 BACKGROUND: Cervical cerclage is a short ambulatory procedure. For spinal anesthesia, local anesthetic agents with rapid postoperative resolution are desired. We hypothesized that in combination with fentanyl, intrathecal 2-chloroprocaine would produce earlier resolution of motor block, resulting in shorter time to meet recovery […]

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Uncategorized Published - 13 July, 2021    By - Dr Clemens
Associations Between Preoperative Biomarkers and Cardiac Surgery–Associated Acute Kidney Injury in Elderly Patients

AUTHORS: Verwijmeren, Lisa MD, PhD et al Anesthesia & Analgesia: June 21, 2021 BACKGROUND: Acute kidney injury (AKI) is associated with mortality after cardiac surgery. Novel risk factors may improve identification of patients at risk for renal injury. The authors evaluated the association between preoperative biomarkers that reflect cardiac, inflammatory, renal, and metabolic disorders and cardiac […]

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Uncategorized Published - 13 July, 2021    By - Dr Clemens
Differential Perioperative Outcomes in Patients With Obstructive Sleep Apnea, Obesity, or a Combination of Both Undergoing Open Colectomy

AUTHORS: Stundner, Ottokar MD, MBA et al Anesthesia & Analgesia: June 21, 2021 BACKGROUND: An increasing body of evidence demonstrates an association between obstructive sleep apnea (OSA) and adverse perioperative outcomes. However, large-scale data on open colectomies are lacking. Moreover, the interaction of obesity with OSA is unknown. This study examines the impact of OSA, obesity, […]

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Uncategorized Published - 13 July, 2021    By - Dr Clemens
P2Y1 Purinergic Receptor Contributes to Remifentanil-Induced Cold Hyperalgesia via Transient Receptor Potential Melastatin 8–Dependent Regulation of N-methyl-d-aspartate Receptor Phosphorylation in Dorsal Root Ganglion

AUTHORS: Su, Lin MD, PhD et al Anesthesia & Analgesia: June 23, 2021 BACKGROUND: Remifentanil can induce postinfusion cold hyperalgesia. N-methyl-d-aspartate receptor (NMDAR) activation and upregulation of transient receptor potential melastatin 8 (TRPM8) membrane trafficking in dorsal root ganglion (DRG) are critical to cold hyperalgesia derived from neuropathic pain, and TRPM8 activation causes NMDAR-dependent cold response. Contribution […]

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Uncategorized Published - 12 July, 2021    By - Dr Clemens
Effects of Local Anesthetic Volume (Standard Versus Low) on Incidence of Hemidiaphragmatic Paralysis and Analgesic Quality for Ultrasound-Guided Superior Trunk Block After Arthroscopic Shoulder Surgery

AUTHORS: Kim, Hyunzu MD, PhD et al Anesthesia & Analgesia: June 28, 2021 BACKGROUND: Relative to interscalene block, superior trunk block (STB) provides comparable analgesia and a reduced risk of hemidiaphragmatic paralysis. However, the incidence of hemidiaphragmatic paralysis remains high when a standard volume (15 mL) of local anesthetic is used. This study aimed to evaluate […]

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Uncategorized Published - 12 July, 2021    By - Dr Clemens
Breast Regional Anesthesia Practice in the Italian Public Health System (BRA-SURVEY)

AUTHORS: Bonvicini, Daniele MD et al Anesthesia & Analgesia: July 7, 2021 – BACKGROUND: Breast cancer is the most common malignancy in women. Surgery is a mainstay therapy unfortunately burdened by complications as severe postoperative pain. Regional anesthesia may play a role in a multimodal strategy for prevention and treatment of postoperative pain. The main purpose […]

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Uncategorized Published - 12 July, 2021    By - Dr Clemens
Effect of conscious sedation and deep sedation on the vagal response characteristics during ganglionated plexus ablation

DG Journal Club Authors: Tolga Aksu, Kivanc Yalin et al. J Cardiovasc Electrophysiol. 2021 Jun 27 We aimed to determine the effects of conscious and deep sedation on vagal response (VR) characteristics during ganglionated plexus (GP) ablation. Forty consecutive patients undergoing GP ablation for vasovagal syncope were divided to receive conscious sedation with midazolam (group […]

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Uncategorized Published - 12 July, 2021    By - Dr Clemens
Postoperative Pain Treatment With Continuous Local Anesthetic Wound Infusion in Patients With Head and Neck Cancer

DG Journal Club Authors: Magdalena Gostian, Johannes Loeser et al. JAMA Otolaryngol Head Neck Surg. 2021 Jun 1; 147(6): 553-560 Importance Up to 80% of patients with head and neck cancer undergoing ablative surgery and neck dissection develop postoperative pain with detrimental effects on quality of life that also contributes to neuropathic and chronic postoperative […]

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Uncategorized Published - 12 July, 2021    By - Dr Clemens
Time for a change? AFib patients may want to stop drinking alcohol

Author: Michael Walter Cardiovascular Business Alcohol consumption is associated with a heightened risk of stroke among patients with newly diagnosed atrial fibrillation (AFib), according to new findings published in European Heart Journal. “Implementation of a healthy lifestyle is an important part of guideline-recommended optimal care of patients with AFib,” wrote first author So-Ryoung Lee, MD, a […]

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