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AUTHORS: Reed, Sydney E. MD et al Anesthesia & Analgesia: May 19, 2021 BACKGROUND: Optimizing analgesia after cesarean delivery is a priority and requires balancing adequate pain relief with the risk of analgesics-associated adverse effects. Current recommendations are for use of a multimodal, opioid-sparing analgesic regimen that includes neuraxial morphine combined with scheduled nonsteroidal anti-inflammatory drugs […]
Read MoreAUTHORS: Gracie, Thomas J. BS et al Anesthesia & Analgesia: May 20, 2021 Abstract BACKGROUND: Both frailty and postoperative delirium (POD) are common in elective surgical patients 65 years of age and older. However, the association between preoperative frailty and POD remains difficult to characterize owing to the large number of frailty and POD assessment tools […]
Read MoreAUTHORS: Packiasabapathy, Senthil MD et al Anesthesia & Analgesia: May 24, 2021 BACKGROUND: Safe postoperative pain relief with opioids is an unmet critical medical need in children. There is a lack of objective, noninvasive bedside tool to assess central nervous system (CNS) effects of intraoperative opioids. Proactive identification of children at risk for postoperative respiratory depression […]
Read MoreAUTHORS: McGuigan, Steven MBChB et al Anesthesia & Analgesia: May 28, 2021 BACKGROUND: Depth-of-anesthesia monitoring is often utilized for patients receiving xenon anesthesia. Processed electroencephalogram (EEG) depth-of-anesthesia monitoring relies to a significant extent on frequency domain analysis of the frontal EEG, and there is evidence that the spectral features observed under anesthesia vary significantly between anesthetic […]
Read MoreAUTHORS: Won, Dongwook MD et al Anesthesia & Analgesia: June 1, 2021 BACKGROUND: Cricoid pressure has been used as a component of the rapid sequence induction and intubation technique. However, concerns have been raised regarding the effectiveness and safety of cricoid pressure. Paratracheal pressure, a potential alternative to cricoid pressure to prevent regurgitation of gastric contents […]
Read MoreAUTHORS: Neff, Thomas A. MD et al Anesthesia & Analgesia: June 16, 2021 BACKGROUND: Postoperative complications in surgery are a significant burden, not only for the patients but also economically. While several predicting factors have already been identified, it is still not well known if increased levels of inflammatory markers in the immediate perioperative phase correlate […]
Read MoreAUTHORS: Zhang, Chengmi MD, PhD et al Anesthesia & Analgesia: June 11, 2021 BACKGROUND: The optimal positive end-expiratory pressure (PEEP) to prevent postoperative pulmonary complications (PPCs) remains unclear. Recent evidence showed that driving pressure was closely related to PPCs. In this study, we tested the hypothesis that an individualized PEEP guided by minimum driving pressure during […]
Read MoreAUTHORS: Zorrilla-Vaca, Andres MD et al Anesthesia & Analgesia: June 11, 2021 BACKGROUND: Opioids are the most commonly prescribed analgesics in the United States. Current guidelines have proposed education initiatives to reduce the risk of chronic opioid consumption, yet there is lack of efficacy data on such interventions. Our study evaluates the impact of perioperative opioid […]
Read MoreAUTHORS: Hooten, W. Michael MD et al Anesthesia & Analgesia: June 21, 2021 BACKGROUND: The adenosine triphosphate-binding cassette, subfamily B, member 1 gene (ABCB1) encodes P-glycoprotein (P-gp) that influences the intracellular transport of solutes including endogenous opioid peptides. The primary objective of this study was to determine the effects of the ABCB1 polymorphism c.3435C>T (rs10454642) on heat pain […]
Read MoreAUTHORS: Kouz, Karim MD et al Anesthesia & Analgesia: June 9, 2021 – BACKGROUND: It remains unknown what constitutes physiologically relevant intraoperative bradycardia. Intraoperative bradycardia is usually defined using absolute heart rate thresholds, ignoring preoperative baseline heart rates. In contrast, we considered defining intraoperative bradycardia relative to preoperative ambulatory nighttime heart rate. Specifically, we hypothesized that […]
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