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Author: Philip J Peyton, MD PhD MBBS FANZCA. Anesthesiology May 2022. Background Inefficiency of lung gas exchange during general anesthesia is reflected in alveolar (end tidal) to arterial (ET-arterial) partial pressure gradients for inhaled gases resulting in an increase in alveolar deadspace. Ventilation-perfusion mismatch is the main contributor to this, but it is unclear what […]
Read MoreAuthors: Swati Agarwal, Ph.D. et al Anesthesiology May 2022. Background Inhalational anesthetics are known to disrupt PDZ2 domain-mediated protein-protein interactions of the postsynaptic density (PSD)-95 protein. The aim of this study is to investigate the underlying mechanisms in response to early isoflurane exposure on synaptic PSD-95 PDZ2 domain disruption that altered spine densities and cognitive […]
Read MoreAuthors: Pervez Sultan, M.B.Ch.B. et al Anesthesiology Newly Published on June 2022. Background Heterogeneity among reported outcomes from enhanced recovery after cesarean delivery impact studies is high. This study aimed to develop a standardized enhanced recovery core outcome set for use in future enhanced recovery after cesarean delivery studies. Methods An international consensus study involving physicians, […]
Read MoreAuthors: Marloes M. Ijland, M.D. et al Anesthesiology May 2022, Vol. 136, 749–762. Background The effect of fluid management strategies in critical illness–associated diaphragm weakness are unknown. This study hypothesized that a liberal fluid strategy induces diaphragm muscle fiber edema, leading to reduction in diaphragmatic force generation in the early phase of experimental pediatric acute respiratory […]
Read MoreAuthors: Erik Olofsen, Ph.D. et al Anesthesiology May 2022, Vol. 136, 792–801. Background Ketamine produces potent analgesia combined with psychedelic effects. It has been suggested that these two effects are associated and possibly that analgesia is generated by ketamine-induced dissociation. The authors performed a post hoc analysis of previously published data to quantify the pharmacodynamic properties of ketamine-induced […]
Read MoreAuthor: Jamie W. Sleigh, M.D. Anesthesiology July 2022, Vol. 137, 4–5. “General anesthesia had rendered the brains of the young patients functionally ‘rigid,’ [which] contrasts with a previous study in adults.” Every human would agree that wakefulness is marked by a succession of experiences—the “stream-of-consciousness.” This implies that the state of the brain is continuously changing […]
Read MoreAuthors: Yuichi Sakaguchi, M.D. et al Anesthesiology July 2022, Vol. 137, 15–27. Background The low acceptance rate of continuous positive airway pressure therapy in postoperative patients with untreated obstructive sleep apnea (OSA) indicates the necessity for development of an alternative postoperative airway management strategy. The authors considered whether the combination of high-flow nasal cannula and upper-body […]
Read MoreAuthor: Evan D. Kharasch, M.D., Ph.D. Anesthesiology June 2022, Vol. 136, 885–887. “It is time to call a MAC (minimum alveolar concentration) a MAC (median alveolar concentration).” Anesthesiology is a specialty grounded in basic and clinical pharmacology. These domains have concepts and vocabularies that are useful to scientists and clinicians, in their understanding and application of […]
Read MoreAuthors: Xi Cen, Ph.D. et al Anesthesiology June 2022. Background Whether a particular surgeon’s opioid prescribing behavior is associated with prolonged postoperative opioid use is unknown. This study tested the hypothesis that the patients of surgeons with a higher propensity to prescribe opioids are more likely to utilize opioids long-term postoperatively. Methods The study identified […]
Read MoreAuthors: Shwethashri Kondavagilu Ramaprasannakumar, M.D., D.M. et al Anesthesiology July 2022, Vol. 137, 79–80. Flexometallic tubes are kink-resistant and extensively used in neurosurgeries. The manufacturers of flexometallic tubes recommend single usage. In low-income countries, due to the cost restraints, flexometallic tubes are commonly reused after ethylene oxide sterilization. With this technique, flexometallic tubes are effectively […]
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