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Authors: Hyun-Jung Shin, M.D., Ph.D. et al Anesthesiology December 2022. Background Delirium is a critical postoperative complication in older patients. Based on the hypothesis that intraoperative dexmedetomidine sedation would lower postoperative delirium than propofol sedation would, the authors compared the incidence of postoperative delirium in older adults, using the mentioned sedatives. Methods This double-blinded, randomized […]
Read MoreAuthors: Jacquot M, Klinefelter et al Pract Pain Manag. 2023 January/February;23(1). With more than 1 in 5 Americans experiencing chronic pain, pain management is an important area of clinical research.¹ Ongoing studies are aimed at developing safe and effective analgesic drugs with a low risk of addiction and overdose.² In late 2022, an update to […]
Read MoreAuthor: Raghuraman M. Sethuraman, M.D. Anesthesiology December 2022. To the Editor: I read the recently published article on pectoral nerve blocks (PECS) for breast augmentation procedures with immense interest. I greatly appreciate the authors for analyzing the efficacy of PECS blocks on breast augmentation procedures and congratulate them for publishing this wonderful study on this topic […]
Read MoreAuthors: Fu-Shan Xue, M.D et al Anesthesiology December 2022. To the Editor: By a randomized, double-blind, dual-centered controlled trial in 73 adult female patients undergoing aesthetic breast augmentation surgery under general anesthesia, Aarab et al. showed that compared to multimodal analgesic regimen alone, pectoral nerve blocks combined with multimodal analgesia significantly improved postoperative pain control and decreased […]
Read MoreNEJM Journal Watch Daniel D. Dressler, MD, MSc, MHM, FACP, reviewing Douketis JD et al. Chest 2022 Nov Douketis JD et al. Chest 2022 Nov New recommendations guide management of perioperative and periprocedural antithrombotic agents. Background In their previous guideline on perioperative antithrombotic management (published a decade ago; Chest 2012;141:2 Suppl:e326S. opens in new tab), the ACCP addressed 11 questions; now, […]
Read MoreAuthors: Cara E. Crouch, M.D. et al Anesthesiology January 2023, Vol. 138, 71–81. Background Postoperative pain associated with open partial hepatectomy can be intense and persistent. The multimodal approach used to lessen this problem includes an intraoperative intravenous infusion of lidocaine hydrochloride. Decreased hepatic metabolism after resection raises concerns about safe lidocaine dosing in this patient […]
Read MoreAuthors: Brian M. Ilfeld, M.D., M.S. et al Anesthesiology January 2023, Vol. 138, 82–97. Background Postamputation phantom pain is notoriously persistent with few validated treatments. Cryoneurolysis involves the application of low temperatures to reversibly ablate peripheral nerves. The authors tested the hypothesis that a single cryoneurolysis treatment would decrease phantom pain 4 months later. Methods The […]
Read MoreAuthors: Scott Greenwald, PhD et al Anesthesiology December 2022. Background We previously reported a broad suite of individualized Risk Stratification Index 3.0 models for various meaningful outcomes in patients admitted to a hospital for medical or surgical reasons. The models used ICD-10 trajectories, and were restricted to information available at hospital admission, including coding history […]
Read MoreNEJM Journal Watch Neil H. Winawer, MD, SFHM And the difference in accuracy might have clinical consequences. Pulse oximeters estimate the oxygen saturation of blood (SpO2) noninvasively by passing two wavelengths of light through the body and measuring the change in absorbance. This reading can be affected by the amount of melanin in the skin, […]
Read MoreAuthors: Pieter Simons, MD et al Anesthesiology December 2022. Background Oliceridine is a G protein-biased µ-opioid, a drug class that is associated with less respiratory depression than non-biased opioids, such as morphine. We quantified the respiratory effects of oliceridine and morphine in elderly volunteers. We hypothesized that these opioids differ in their pharmacodynamic behavior, measured […]
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