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Authors: Amir Hossein Irani, Ph.D. et al Anesthesiology February 2023, Vol. 138, 152–163. Background The clinical actions of sugammadex have been well studied, but the detailed molecular mechanism of the drug encapsulation process has not been systematically documented. The hypothesis was that sugammadex would attract rocuronium and vecuronium via interaction with the sugammadex side-chain “tentacles,” as previously suggested. […]
Read MoreAuthors: Philip J Peyton, MD PhD MBBS FANZCA et al Anesthesiology January 2023. Background Nitrous oxide (N2O) promotes absorption atelectasis in poorly ventilated lung segments at high inspired concentrations. The ENIGMA Trial found a higher incidence of postoperative pulmonary complications (PPCs) and wound sepsis with N2O anesthesia in major surgery compared to FIO2 0.8 without N2O. […]
Read MoreAuthor: Patsy Newitt Becker’s ASC Review Nine ASC leaders joined Becker’s to discuss the biggest threats to the industry. Editor’s note: These responses were edited lightly for brevity and clarity. 1. Increasing operating costs: Brenda Carter. Administrator of Wilmington (N.C.) Surgcare: With ongoing supply chain issues, increased supply and equipment costs and the ever-increasing need to push salaries […]
Read MoreAuthors: Naheed K. Jivraj, M.B.B.S., M.Sc. et al Anesthesiology February 2023, Vol. 138, 195–207. Background The objective was to assess changes over time in prescriptions filled for nonopioid analgesics for older postoperative patients in the immediate postdischarge period. The authors hypothesized that the number of patients who filled a nonopioid analgesic prescription increased during the study […]
Read MoreAuthors: Aranke M et al Pract Pain Manag. 2023 January/February;23(1). Introduction Chemotherapy-induced peripheral neuropathy (CIPN) affects between 40% and 70% of individuals undergoing chemotherapy and may significantly affect quality of life by worsening symptomatic clusters, such as psychological distress, fatigue-related pain, and abdominal discomfort.¹˒² There are several proposed mechanisms for CIPN. These range from the […]
Read MoreAuthor: Enrico Giustiniano, M.D.; Fulvio Nisi, M.D. Anesthesiology January 2023. To the Editor: We read with interest the article by Enevoldsen and Vistisen about the predictive model of intraoperative hypotension. Regarding the criticism the authors made about what they named “gray-zone outcome,” we would like to provide some comments. The Hypotension Prediction Index is a new parameter […]
Read MoreAutors: Johannes Enevoldsen, M.D. et al Anesthesiology January 2023. In Reply: We have read the interesting comment by Giustiniano and Nisi about our article. The authors highlight that the diastolic arterial blood pressure can decrease significantly when the Hypotension Prediction Index (hereafter the Index) reaches approximately 50 and argue for the possible need for treatment when diastolic arterial […]
Read MoreAuthors: Hao Xiao, M.S. et al Anesthesiology January 2023. Background Chlorhexidine generally has a good safety profile. However, allergic reactions are reported with increasing frequency. In China, it is rarely reported, and its characteristics are unknown. The purpose of this study was to summarize the experience of a Chinese allergy centre with chlorhexidine allergy. Methods […]
Read MoreAUTHORS: Cohen, William G. BA et al Anesthesia & Analgesia November 02, 2022. BACKGROUND: Ketorolac-refractory pain behavior following bilateral myringotomy and pressure equalization tube placement (BMT) is associated with the absence of middle ear fluid. Intraoperative fentanyl/ketorolac affords more reliable pain control than ketorolac alone. We hypothesized that middle ear condition would correlate with postoperative […]
Read MoreAuthor: Doheny K. Pract Pain Manag. 2023 January/February;23(1). Migraine affects at least 39 million US adults, according to the Association of Migraine Disorders,¹ causing lost workdays, time away from family, and other quality of life issues. Worldwide, about 10% of people are affected by migraine and women are three times as likely to be affected […]
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