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Authors: Dong Zhang, PhD et al Anesthesiology April 2023. Background The administration of epinephrine after severe refractory hypotension, shock or cardiac arrest restores systemic blood flow and major vessel perfusion but may worsen cerebral microvascular perfusion and oxygen delivery through vasoconstriction. We hypothesized that epinephrine induces significant microvascular constriction in the brain, with increased severity […]
Read MoreСаrdiac Anesthesiologist April 2023 Propofol and thiopental sodium are both intravenous anesthetic agents used for the induction of anesthesia, but there are several differences between the two agents: Onset and duration of action: Propofol has a more rapid onset of action compared to thiopental sodium, meaning it takes effect more quickly after administration. Propofol also has […]
Read MoreAuthor: Heidi Splete Practical Pain Management Volume 23 Issue 2 Hospitalizations for acute liver failure involving acetaminophen and opioid toxicity decreased significantly after the FDA mandated limiting acetaminophen to 325 mg in combination acetaminophen and opioid products over a decade ago. Previous research suggested that 40% to 58% of cases of acute liver failure (ALF) […]
Read MoreThe Daily Dose Anesthesiology International Anesthesia Research Society Jane S. Moon, MD There is a pressing need to recruit, retain, and promote a diverse physician anesthesiologist workforce to encourage equity in healthcare delivery, as well as innovation and inclusivity in the workplace. This topic was the focus of “Diversity in Academic Anesthesiology: Enhancing the Workforce,” […]
Read MoreAuthor: Catherine L. Chen, MD, MPH ASA Monitor June 2023, Vol. 87, 37. When I received my first FAER Research Fellowship Grant to study unnecessary routine preoperative testing in Medicare cataract surgery patients as a CA-2 resident in 2013, I could not have predicted that I would still be studying the delivery of cataract surgery care […]
Read MoreAuthors: Andrew Bowdle, MD, PhD, FASE et al Anesthesiology April 2023. Background The dose of sugammadex recommended by the manufacturer for reversal of rocuronium is 2 mg/kg when the train-of-four count is 2 or more and 4 mg/kg when it is less than 2 but there is a post-tetanic count of at least 1. The purpose of […]
Read MoreСаrdiac Anesthesiologist April 2023 Ketamine is a powerful anesthetic drug that has been used in medical settings for decades. However, its effects on the brain have also led to its use as a recreational drug, leading to controversy surrounding its use. Despite its negative associations, recent research has shown promising potential for the drug in the […]
Read MoreAuthors: Emily P. Mihalko, Ph.D et al Anesthesiology April 2023. Background The use of low-titer group O whole blood is increasing. To reduce wastage, unused units can be converted to packed red blood cells. Supernatant is currently discarded post-conversion; however, it could be a valuable transfusable product. The aim of this study was to evaluate […]
Read MoreAuthors: Kira A Spencer, Ph.D. et al Anesthesiology Newly Published on April 2023. Background. A variety of molecular targets for volatile anesthetics have been suggested including the anesthetic-sensitive K+ leak channel, TREK-1. Knockout of TREK-1 is reported to render mice resistant to volatile anesthetics, making TREK-1 channels compelling targets for anesthetic action. Spinal cord slices from mice, […]
Read MoreAuthors: Andrew S Chang, MS et al Anesthesiology April 2023. Background Suppression of behavioral and physical responses defines the anesthetized state. This is accompanied, in humans, by characteristic changes in EEG patterns. However, these measures reveal little about the neuron or circuit-level physiological action of anesthetics, nor how information is trafficked between neurons. We assess […]
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