Author: Dr Clemens

Uncategorized Published - 4 March, 2024    By - Dr Clemens
Melanin-Concentrating Hormone Is Associated With Delayed Neurocognitive Recovery in Older Adult Patients With Preoperative Sleep Disorders Undergoing Spinal Anesthesia

AUTHORS: Gao, Yi MS et al  Anesthesia & Analgesia 138(3):p 579-588, March 2024. BACKGROUND: Aging and preoperative sleep disorders are the main risk factors affecting postoperative cognitive outcomes. However, the pathogenesis of delayed neurocognitive recovery after surgery remains ambiguous, and there is still a lack of potential biomarkers for delayed neurocognitive recovery in older adult patients […]

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Uncategorized Published - 4 March, 2024    By - Dr Clemens
Inhibition of Cyclophilin A-Metalloproteinase-9 Pathway Alleviates the Development of Neuropathic Pain by Promoting Repair of the Blood-Spinal Cord Barrier

AUTHORS: Wang, Yu MD et al  Anesthesia & Analgesia November 23, 2023. | BACKGROUND: Dysfunction of the blood-spinal cord barrier (BSCB) contributes to the occurrence and development of neuropathic pain (NP). Previous studies revealed that the activation of cyclophilin A (CypA)-metalloproteinase-9 (MMP9) signaling pathway can disrupt the integrity of the blood-brain barrier (BBB) and aggravate neuroinflammatory […]

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Uncategorized Published - 1 March, 2024    By - Dr Clemens
Daily marijuana use increases heart failure risk by 34%

Author: Michael Walter Cardiovascular Business Regular marijuana use may significant increase a person’s risk of developing heart failure, according to new research presented at the American Heart Association’s Scientific Sessions 2023 in Philadelphia. “Prior research shows links between marijuana use and cardiovascular disease like coronary artery disease, heart failure and atrial fibrillation, which is known to cause heart […]

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Uncategorized Published - 1 March, 2024    By - Dr Clemens
Artificial Intelligence in Anesthetic Care

AUTHORS: Estrada Alamo, Carlos E. MD, MBA et al   Anesthesia & Analgesia December 07, 2023. BACKGROUND: This study explored physician anesthesiologists’ knowledge, exposure, and perceptions of artificial intelligence (AI) and their associations with attitudes and expectations regarding its use in clinical practice. The findings highlight the importance of understanding anesthesiologists’ perspectives for the successful integration […]

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Uncategorized Published - 1 March, 2024    By - Dr Clemens
Quercetin, Main Active Ingredient of Moutan Cortex, Alleviates Chronic Orofacial Pain via Block of Voltage-Gated Sodium Channel

AUTHORS: Liu, Zhanli MD et al  Anesthesia & Analgesia November 17, 2023. BACKGROUND: Chronic orofacial pain (COP) therapy is challenging, as current medical treatments are extremely lacking. Moutan Cortex (MC) is a traditional Chinese medicine herb widely used for chronic inflammatory diseases. However, the mechanism behind MC in COP therapy has not been well-established. The […]

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Uncategorized Published - 1 March, 2024    By - Dr Clemens
Low Perfusion and Missed Diagnosis of Hypoxemia by Pulse Oximetry in Darkly Pigmented Skin

AUTHORS: Gudelunas, M. Koa BS et al  Anesthesia & Analgesia 138(3):p 552-561, March 2024. BACKGROUND: Retrospective clinical trials of pulse oximeter accuracy report more frequent missed diagnoses of hypoxemia in hospitalized Black patients than White patients, differences that may contribute to racial disparities in health and health care. Retrospective studies have limitations including mistiming of blood […]

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Uncategorized Published - 1 March, 2024    By - Dr Clemens
Novel Preoperative Risk Stratification Using Digital Phenotyping Applying a Scalable Machine-Learning Approach

AUTHORS: Laferrière-Langlois, Pascal MD, MS et al  Anesthesia & Analgesia December 05, 2023. | BACKGROUND: Classification of perioperative risk is important for patient care, resource allocation, and guiding shared decision-making. Using discriminative features from the electronic health record (EHR), machine-learning algorithms can create digital phenotypes among heterogenous populations, representing distinct patient subpopulations grouped by shared characteristics, […]

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Uncategorized Published - 29 February, 2024    By - Dr Clemens
Poor Agreement Between Preoperative Transthoracic Echocardiography and Intraoperative Transesophageal Echocardiography for Grading Diastolic Dysfunction

AUTHORS: McIlroy, David R. MBBS, MD, MClinEpi, FANZCA et al  Anesthesia & Analgesia 138(1):p 123-133, January 2024. BACKGROUND: Guidelines for the evaluation and grading of diastolic dysfunction are available for transthoracic echocardiography (TTE). Transesophageal echocardiography (TEE) is used for this purpose intraoperatively but the level of agreement between these 2 imaging modalities for grading diastolic dysfunction […]

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Uncategorized Published - 29 February, 2024    By - Dr Clemens
Association Between Loop Diuretics and Mortality in Patients With Cardiac Surgery–Associated Acute Kidney Injury

AUTHORS: Zhu, Shouqiang MD et al Anesthesia & Analgesia November 22, 2023. BACKGROUND: Although loop diuretics (LDs) have been widely used in clinical practice, their effect on mortality when administered to patients experiencing cardiac surgery–associated acute kidney injury (CS-AKI) remains unknown. The study aimed to investigate the effectiveness of LD use in patients with CS-AKI. […]

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Uncategorized Published - 29 February, 2024    By - Dr Clemens
A closer look at how weight loss drug semaglutide improves the cardiovascular health of obese patients without diabetes

Author: Michael Walter Cardiovascular Business | Weekly treatments of semaglutide can reduce the risk of cardiovascular death, heart attack or stroke among obese patients without diabetes, according to new data presented at the American Heart Association’s Scientific Sessions 2023 conference and simultaneously published in The New England Journal of Medicine.[1] Subcutaneous treatments of semaglutide, a GLP-1 receptor agonist […]

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