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Published in Lancet Neurol 2015 Feb 14:162 Authors: Finnerup NB et al. Results of a meta-analysis and systematic review Neuropathic pain is a serious chronic condition affecting quality of life that can be relieved but not cured. The estimated prevalence is at least 1% to 5% of the general population (Pain Pract 2014; 14:283). Neuropathic […]
Read MorePublished in Circulation 2015 Jan 27; 131:362 Authors: Culler SD et al. Published in Circulation 2015 Jan 27; 131:362 Findings from an analysis of two national Medicare databases To determine recent trends in coronary revascularization among Medicare beneficiaries, researchers analyzed two national administrative databases. The data covered inpatient and outpatient percutaneous coronary interventions (PCIs) and […]
Read MoreAnesthesiology used to be a job that was attractive for people who don’t like patients very much. The drill was: Meet patient 5 minutes before surgery, do case in OR without interruption, drop off in PACU, done. Minimal need for personal interaction with patient, no need to listen to complaints about back pain and demands […]
Read MorePublished in Anesthesiology 2015 Jan 122:21 Authors: Clifford L et al. Transfusion-related acute lung injury and transfusion-associated circulatory overload occurred in several percent of transfused patients. Transfusion-related acute lung injury (TRALI) and transfusion-associated circulatory overload (TACO) are important causes of morbidity and mortality in transfused patients. Mayo Clinic researchers conducted two retrospective studies to determine […]
Read MorePublished in Ann Emerg Med 2015 Jan 7 Authors: Schaffer JT et al. Intranasal lidocaine has shown promise as a migraine treatment, but a trial of bupivacaine for unselected headaches disappoints. Prior research has shown intranasal lidocaine to be an effective treatment for migraine (NEJM JW Emerg Med Aug 16 1996). Now, investigators report results […]
Read MorePublished in J Pediatr 2014 Dec 165:1230 Authors: Adelgais KM et al. Abdominal tenderness, more than abdominal pain, predicted intra-abdominal injury and need for acute intervention. To evaluate the accuracy of patient-reported abdominal pain and physician-assessed abdominal tenderness for predicting intra-abdominal injuries in children, investigators conducted a planned secondary analysis of patients <18 years of […]
Read MoreOpioids are frequently prescribed to reproductive-aged women in the U.S., raising concerns about fetal exposure in unrecognized or unintended pregnancies, an MMWR article finds. Opioid exposure during pregnancy is potentially associated with increased risks for neonatal abstinence syndrome and birth defects. CDC researchers examined two databases — one of Medicaid recipients and the other of […]
Read MorePublished in Anesthesiology 2015 Jan 122:29 Authors: Pinheiro de Almeida J et al. A hemoglobin level of 9 g/dL was superior to 7 g/dL as a trigger for transfusion. Randomized trials have shown favorable outcomes with a restrictive red-cell transfusion strategy — that is, not transfusing until hemoglobin levels are <7 g/dL in general critical-care […]
Read MoreFood and Drug Administration (US) AUDIENCE: Pharmacy, Case Manager ISSUE: Hospira announced a voluntary recall of ketorolac tromethamine injection, USP in the United States and Singapore due to potential particulate. The presence of particulate has been confirmed through a customer report of visible, floating particulate identified in glass fliptop vials. The particulate was identified as […]
Read MorePublished in The Journal of the American Society of Anesthesiologists on 1 2015. Authors: Nicholas P. Franks, F.R.C.A., F.Med.Sci., F.R.S. Background: Most anesthetics, particularly intravenous agents such as propofol and etomidate, enhance the actions of the neurotransmitter γ-aminobutyric acid (GABA) at the GABA type A receptor. However, there is no agreement as where anesthetics bind […]
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