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Published in J Pediatr 2014 Dec 165:1230 Authors: Adelgais KM et al. Abdominal tenderness, more than abdominal pain, predicted intra-abdominal injury and need for acute intervention. To evaluate the accuracy of patient-reported abdominal pain and physician-assessed abdominal tenderness for predicting intra-abdominal injuries in children, investigators conducted a planned secondary analysis of patients <18 years of […]
Read MoreOpioids are frequently prescribed to reproductive-aged women in the U.S., raising concerns about fetal exposure in unrecognized or unintended pregnancies, an MMWR article finds. Opioid exposure during pregnancy is potentially associated with increased risks for neonatal abstinence syndrome and birth defects. CDC researchers examined two databases — one of Medicaid recipients and the other of […]
Read MorePublished in Anesthesiology 2015 Jan 122:29 Authors: Pinheiro de Almeida J et al. A hemoglobin level of 9 g/dL was superior to 7 g/dL as a trigger for transfusion. Randomized trials have shown favorable outcomes with a restrictive red-cell transfusion strategy — that is, not transfusing until hemoglobin levels are <7 g/dL in general critical-care […]
Read MoreFood and Drug Administration (US) AUDIENCE: Pharmacy, Case Manager ISSUE: Hospira announced a voluntary recall of ketorolac tromethamine injection, USP in the United States and Singapore due to potential particulate. The presence of particulate has been confirmed through a customer report of visible, floating particulate identified in glass fliptop vials. The particulate was identified as […]
Read MorePublished in The Journal of the American Society of Anesthesiologists on 1 2015. Authors: Nicholas P. Franks, F.R.C.A., F.Med.Sci., F.R.S. Background: Most anesthetics, particularly intravenous agents such as propofol and etomidate, enhance the actions of the neurotransmitter γ-aminobutyric acid (GABA) at the GABA type A receptor. However, there is no agreement as where anesthetics bind […]
Read MorePublished in The Journal of the American Society of Anesthesiologists on 1 2015. Authors: Lianyan Huang, Ph.D.; Guang Yang, Ph.D. Background: Recent studies in rodents suggest that repeated and prolonged anesthetic exposure at early stages of development leads to cognitive and behavioral impairments later in life. However, the underlying mechanism remains unknown. In this study, […]
Read MorePublished in The Journal of the American Society of Anesthesiologists in 1 2015. Authors: Jochen D. Muehlschlegel, M.D. et al Danos C. Christodoulou, Ph.D. Background: The exact mechanisms that underlie the pathological processes of myocardial ischemia in humans are unclear. Cardiopulmonary bypass with cardioplegic arrest allows the authors to examine the whole transcriptional profile of […]
Read MoreAuthors: Ikuomi Mikuni, M.D., Ph.D. et al Published in The Journal of the American Society of Anesthesiologists on 1 2015. Background: The impact of volatile anesthetics on patients with inherited long QT syndrome (LQTS) is not well understood. This is further complicated by the different genotypes underlying LQTS. No studies have reported on the direct […]
Read MoreAuthors: Webster L, Smith M, Mackin S, Iverson M Published in Pain Medicine (Oct 2014) OBJECTIVE To investigate effects of extended-release (ER) hydromorphone dosing time (morning, QAM; evening, QPM) on sleep physiology in patients with chronic low back pain. DESIGN Randomized, double-blind, placebo-controlled, crossover trial. SETTING Clinical research site. PATIENTS Fifteen patients with moderate-to-severe chronic low […]
Read MorePublished in Der Anaesthesist (Oct 2014) Authors: Zech N, Seemann M, Hansen E; Anesthetists have an impact on patients and healing processes not only through drugs, interventions and therapy but also significantly by their words and personality. A substantial part of observed side effects is caused by nocebo effects and negative suggestion, i.e. by the doctor […]
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