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There is insufficient evidence to determine the effectiveness of long-term opioid therapy for improving chronic pain, but emerging data support a dose-dependent risk for serious harms, such as overdose, mortality, and possibly fractures and cardiovascular events, according to a new review. Most opioid-related studies lasted less than 12 weeks (and many less than 6 weeks), […]
Read MorePublished in Clin Interv Aging. 2014 Dec 16;10:1-11 Authors: Guerriero F et al PURPOSE: Chronic pain is highly prevalent in older adults. Increasing evidence indicates strong opioids as a valid option for chronic pain management in geriatrics. The aim of this study was to evaluate efficacy and safety of low-dose oral prolonged-release oxycodone-naloxone (OXN-PR) in […]
Read MorePublished in Lancet Neurol. 2015 Feb;14(2):162-73 Authors: Finnerup NB et al BACKGROUND: New drug treatments, clinical trials, and standards of quality for assessment of evidence justify an update of evidence-based recommendations for the pharmacological treatment of neuropathic pain. Using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE), we revised the Special Interest Group on […]
Read MoreInterventional spine procedures have low same-day complication rates, according to an analysis of 26,151 such procedures performed at several centers in the United States. Less than 0.1% of the procedures resulted in a transfer to an emergency department (ED) or an aborted procedure, according to a presentation at the International Spine Intervention Society’s (ISIS) annual […]
Read MoreA review of the records of more than 20,000 women in labor has found that even those with platelet counts as low as 50×109/L can safely receive regional anesthesia (RA), under the right circumstances. Although RA is now the standard of care in laboring women, turning to epidurals and spinals in high-risk parturients—especially those with […]
Read MoreWhen it comes to complications from tracheal intubation, mucosal burns are not often at the forefront of anesthesiologists’ concerns, but perhaps they should be. Research has concluded that the bulbs in older laryngoscopes can quickly and easily generate temperatures that can cause mucosal damage, a problem obviated by the use of LED bulbs. According to […]
Read MoreIn nearly all cases in which patients suffered accidental awareness during general anesthesia, a neuromuscular block (NMB) was also given, despite NMBs being routinely used less than half the time when anesthesia is administered. So concluded the largest and most comprehensive study of accidental awareness to date. Of the patients who reported accidental awareness, 93% […]
Read MorePublished in Acta Anaesthesiol Scand. 2015 Mar;59(3):406-7 Authors: D’souza S et al Abstract A descriptive case report of a 22-year-old woman, scheduled for elective laparotomy who had a respiratory arrest after premedication with inj glycopyrrolate and ondansetron. Respiratory arrest is an uncommon side effect of glycopyrrolate with very few published reports. Ondansteron can also cause […]
Read MorePublished in Anaesth Crit Care and Pain. 2014;14(5):224-229 Authors: Susan M Nimmo MB ChB FRCA FFPMRCA FRCPEdin MSc Pain Medicine et al Many of the benefits of effective epidural analgesia for open abdominal surgery are soundly established. A well-managed epidural can provide excellent analgesia in the postoperative period allowing the patient to be pain free […]
Read MoreIn a drug safety communication issued today, the US Food and Drug Administration (FDA) says it is aware of recent reports “questioning” the safety of prescription and over-the-counter (OTC) pain medicines when used during pregnancy, but that it lacks adequate studies to change current recommendations. The benefits and risks of using prescription and OTC pain […]
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