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Published in Pharmacotherapy. 2015 Jan;35(1):112-7 Authors: Hillman AD et al Abstract Serotonin syndrome is a syndrome identified by a triad of altered mental status, neuromuscular overactivity, and autonomic instability caused by the overstimulation of serotonin in the central nervous system and periphery. Serotonin syndrome may be provoked with the addition or increase in serotonergic agents such […]
Read MorePublished in Foot Ankle Int. 2015 May;36(5):503-7 Authors: Robbins J et al BACKGROUND: Liposomal bupivacaine is increasingly being utilized in attempts to provide prolonged local analgesia in the immediate postoperative period. The purpose of this study was to quantify the reduction in opioid consumption as well as postoperative pain scores in the postoperative period when liposomal […]
Read MoreIn a drug safety communication issued today, the US Food and Drug Administration (FDA) says it is aware of recent reports “questioning” the safety of prescription and over-the-counter (OTC) pain medicines when used during pregnancy, but that it lacks adequate studies to change current recommendations. The benefits and risks of using prescription and OTC pain […]
Read MoreOpioid pain medications are widely prescribed among women of childbearing age, which is a “significant public health concern,” federal health officials with the Centers for Disease Control and Prevention said today. A new report published in the January 23 issue of Morbidity and Mortality Weekly Report (MMWR) shows that roughly one fourth of privately insured women aged 15 to […]
Read MoreThe use of ultrasound to measure airway dimensions in order to predict difficult intubations has been proven reliable, potentially opening the door for its use in such situations. “The difficulty of airway management is one of the prime risks for mortality and morbidity in patients undergoing anesthesia,” said Faraj W. Abdallah, MD, assistant professor of […]
Read MoreAuthors: Holcomb JB et al. JAMA 2015 Feb 3. Compared with a 1:1:2 ratio, the 1:1:1 ratio improved hemostasis without causing more adverse effects, although mortality did not differ. In recent years, the dogma regarding large-volume crystalloid resuscitation in trauma patients has changed, with increased emphasis on including plasma and platelets in addition to red blood cells […]
Read MoreDespite effective new treatments for their disease, children with pulmonary hypertension (PHT) are still a high-risk group for serious complications and death related to anaesthesia and surgery, according to a study published in the February issue of the journal Anesthesia & Analgesia. “The risk for adverse events during anaesthesia in patients with PHT remains high, […]
Read MoreTreating post-operative pain with morphine can cause life-threatening respiratory problems in some children who have had their tonsils and/or adenoids removed, according to a study published in the January 26, 2015, online edition of the journal Pediatrics. The study has identified a significant risk for potentially-fatal breathing disruption when morphine is administered at home after […]
Read MoreIt is disturbingly common, dangerously lethal and difficult to diagnose, yet propofol-related infusion syndrome (PRIS) may be detected before it happens, given proper vigilance by anesthesiologists. Indeed, research has found a positive correlation between the duration of propofol infusion and increasing triglyceride (TG) levels, which may indicate onset of the deadly complication. “Obviously, propofol has […]
Read MorePublished in Clinical Interventions in Aging 10 1-11 (2015) Authors: Guerriero F et al PURPOSE Chronic pain is highly prevalent in older adults. Increasing evidence indicates strong opioids as a valid option for chronic pain management in geriatrics. The aim of this study was to evaluate efficacy and safety of low-dose oral prolonged-release oxycodone-naloxone (OXN-PR) in […]
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