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Authors: Rasmus Vestergaard Juul, M.SC et al Anesthesiology 12 2015, Vol.123, 1411-1419 Background: Reduction in consumption of opioid rescue medication is often used as an endpoint when investigating analgesic efficacy of drugs by adjunct treatment, but appropriate methods are needed to analyze analgesic consumption in time. Repeated time-to-event (RTTE) modeling is proposed as a way to describe analgesic […]
Read MoreAuthors: Neumar RW et al., Circulation 2015 Nov 3; 132:S315 Push hard and fast — but not too hard or too fast! Sponsoring Organization: American Heart Association (AHA) Target Population: Lay public, healthcare providers Background and Objective The AHA has released an evidence-based update to its 2010 guidelines for cardiopulmonary resuscitation (CPR) and emergency cardiovascular care. Key Points Adult […]
Read MoreAuthor: Robbins MS et al., Neurology 2015 Sep 22; 85:1024 New findings from a hospital-based retrospective study suggest some differences in primary versus secondary headache characteristics in this population. In this retrospective chart review, researchers describe demographics, comorbidities, and clinical features of acute headache in pregnant women who received a neurological consultation for headache at one hospital […]
Read MoreAuthors: Naveed Siddiqui MD M.Sc et al Anesthesiology 11 2015, Vol.123, 1033-1041. Background: Misidentification of the cricothyroid membrane in a “cannot intubate-cannot oxygenate” situation can lead to failures and serious complications. The authors hypothesized that preprocedure ultrasound-guided identification of the cricothyroid membrane would reduce complications associated with cricothyrotomy. Methods: A group of 47 trainees were randomized to digital palpation […]
Read MoreAuthors: Knji, M.D. et al Anesthesiology published on 10 2015 Background: The purpose of this study is to assess the rates of perioperative medication errors (MEs) and adverse drug events (ADEs) as percentages of medication administrations, to evaluate their root causes, and to formulate targeted solutions to prevent them. Methods: In this prospective observational study, anesthesia-trained study staff […]
Read MoreAmong infants undergoing hernia repair, general anesthesia for less than an hour does not adversely affect early neurodevelopmental outcomes, according to an international study published in the Lancet. Over 700 infants up to 60 weeks of age being treated for inguinal hernia were randomized to receive either general anesthesia with sevoflurane or awake-regional anesthesia with caudal […]
Read MoreUse of clinician-recommended prescription opioids before the end of high school is associated with later opioid misuse — particularly among those high-schoolers who seem least likely to misuse drugs — a Pediatrics study finds. Researchers studied a nationally representative sample of 6200 youth who, in grade 12, completed questionnaires about drug use and then were followed up […]
Read MoreAm J Emerg Med 2015 Sep;33(9):1205-8. Authors: Fathi M et al OBJECTIVES: This randomized clinical trial compares the efficacy and safety of oral oxycodone (an oral opioid) with naproxen (a nonsteroidal anti-inflammatory drug) in acute pain control in patients with soft tissue injury. It also evaluates the need for additional doses of analgesics in the first 24 […]
Read MoreTwo analyses of the safety and efficacy of serotonin (5-HT3) receptor antagonists suggest that the most effective therapies for perioperative vomiting are ondansetron plus droperidol IV and granisetron plus dexamethasone (BMC Med 2015;13:136 and 142). Granisetron plus dexamethasone was also found to be one of the most effective therapies for nausea and for postoperative nausea and […]
Read MoreDose–Response Relationship in Cardiac Surgery: Ottawa, Ontario, Canada—Cardiac anesthesiologists can add acute kidney injury (AKI) to the many deleterious effects of intraoperative hypotension. A retrospective cohort study by a team of Canadian investigators found a relationship between kidney injury and mean arterial pressure (MAP) less than 65 mm Hg, but also uncovered evidence of a […]
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