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Published in Paediatr Anaeth 2015 May; 25 Authors: Ibacache ME et al BACKGROUND: The use of dexmedetomidine-ketamine combination to perform different diagnostic and surgical pediatric procedures has increased. The optimal ketamine dose to combine with dexmedetomidine has not been determined. The goal of this study was to determine the ED50 and ED95 of ketamine, which in […]
Read MorePublished in Paediatr Anaesth 2015 Jul;25(7):711-8 Authors: Anell-Olofsson M et al BACKGROUND: Administration of local anesthetics by a surgically placed wound catheter has recently been shown to reduce the need for postoperative morphine administration in extremely preterm infants undergoing ductus ligation. The primary aim of this randomized safety study was to define the plasma levels of […]
Read MoreUsing special magnetic resonance imaging (MRI), researchers have identified which patients will go on to develop chronic pain, disability, and post-traumatic stress disorder (PTSD) 1 to 2 weeks following whiplash injuries. This is the earliest these patients have ever been identified, according to James Elliott, MD, Northwestern University Feinberg school of Medicine, Chicago, Illinois, and […]
Read MoreCombining morphine and nortriptyline has been found to successfully relieve chronic neuropathic pain in 87% of patients, and significantly better than with either drug alone, according to a study published in the journal Pain. “Chronic pain is an increasingly common problem and can exert disastrous personal, societal, and socio-economic impacts on patients, their families, and […]
Read MoreLike all workers, anesthesiologists must determine the best ways to serve their “customers”—the hospital, surgeons, patients and bill payors. Although it is important to make each group happy, the “real” customers are the hospital administrators who renew contracts. Administrators should know your value and how your anesthesia practice is indispensable to the hospital. “This is […]
Read MoreAlthough 15 years have passed since the last airway injury analysis of the American Society for Anesthesiologists (ASA) Closed Claims Project, new research reveals that pharyngeal and esophageal perforations continue to be a significant source of patient morbidity and mortality—as well as liability for anesthesiologists. The investigators noted, however, that practitioner diligence is key to […]
Read MorePublished in Acta Anaestesiol Scand 2015 Apr;59(4):414-26 Authors: Heesen M et al BACKGROUND: Intravenous ketamine has been used during general and regional anaesthesia for caesarean section. No systematic review and meta-analysis on the desired effects and adverse effects of ketamine administration during caesarean section have yet been performed. METHODS: After a systematic literature search a meta-analysis was […]
Read MorePublished in Acta Anaesthesiol Scand. 2015 Apr;59(4):496-504 Authors: Telnes A et al BACKGROUND: Multiple studies suggest that transversus abdominis plane (TAP) block (without intrathecal morphine) after Caesarean section (CS) reduces post-operative morphine consumption. In our study, we wanted to compare the analgesic effect of TAP block with infiltration of the wound after CS. METHODS: We included […]
Read MoreAuthors: Mouncey PR et al., N Engl J Med 2015 Apr 2; 372:1301 A third trial shows no benefit for early goal-directed therapy for septic shock. In 2001, a single-center randomized trial demonstrated a significant mortality benefit for early goal-directed therapy (EGDT) in patients with septic shock (NEJM JW Gen Med Dec 15 2001 and N Engl J Med 2001; […]
Read MoreOpioid-induced hyperalgesia is among the most pressing concerns in the national discussion of opioid addiction, underscored by the US Food and Drug Administration’s (FDA) call for clinical trials to better understand the risks, but the issue is mired in more complexities and confusion than many may even realize, an expert says. Norman Harden, MD, from […]
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