Author: Dr Clemens

Uncategorized Published - 14 July, 2015    By - Dr Clemens
The ED90 of Prophylactic Oxytocin Infusion After Delivery of the Placenta During Cesarean Delivery in Laboring Compared with Nonlaboring Women: An Up-Down Sequential Allocation Dose-Response Study

Anesthesia & Analgesia: July 2015 Volume 121 pages 159-164 Authors: Lavoie, Anne MD et al BACKGROUND: Prophylactic administration of oxytocin as a part of active management of the third stage of labor reduces the risk of postpartum hemorrhage. Prophylactic oxytocin is often administered as an infusion rather than a bolus. The aim of the current […]

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Uncategorized Published - 14 July, 2015    By - Dr Clemens
Sedation-Analgesia with Propofol and Remifentanil: Concentrations Required to Avoid Gag Reflex in Upper Gastrointestinal Endoscopy

Anesthesia & Analgesia: July 2015 Volume 121 page 90-96 Authors: Borrat, Xavier MD  et al BACKGROUND: The purpose of this study was to identify optimal target propofol and remifentanil concentrations to avoid a gag reflex in response to insertion of an upper gastrointestinal endoscope. METHODS: Patients presenting for endoscopy received target-controlled infusions (TCI) of both […]

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Uncategorized Published - 14 July, 2015    By - Dr Clemens
The Incidence of Perioperative Hypersensitivity Reactions: A Single-Center, Prospective, Cohort Study

Anesthesia & Analgesia: July 2015 Volume 121 page 117-123 Authors: Berroa, Felicia MD, PhD et al BACKGROUND: The incidence of perioperative hypersensitivity reactions, which can be life-threatening, ranges from 1 in 20,000 to 1 in 1361. These reactions are usually classified as IgE or non-IgE mediated. The aim of this study was to determine the […]

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Uncategorized Published - 13 July, 2015    By - Dr Clemens
A Multicenter Evaluation of a Closed-Loop Anesthesia Delivery System: A Randomized Controlled Trial

Published in Anesthesia & Analgesia: April 2015 Authors: Puri, Goverdhan D. MD, PhD et al BACKGROUND: Closed-loop systems for anesthesia delivery have been shown to outperform traditional manual control in different clinical settings. The present trial was aimed at evaluating the feasibility and efficacy of Bispectral Index (BISTM)-guided closed-loop anesthesia delivery system (CLADS) in comparison […]

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Uncategorized Published - 13 July, 2015    By - Dr Clemens
The Effect of Adding a Background Infusion to Patient-Controlled Epidural Labor Analgesia on Labor, Maternal, and Neonatal Outcomes: A Systematic Review and Meta-Analysis

Anesthesia & Analgesia: April 2015  Issue 1 page 149-158 Authors: Heesen, Michael MD et al BACKGROUND: Patient-controlled epidural analgesia (PCEA) has gained popularity, but it is still unclear whether adding a background infusion confers any benefit. METHODS: A systematic literature search in PubMed, Embase, CINAHL, LILACS, CENTRAL, Clinicaltrials.gov, and ISI WOS was performed to identify […]

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Uncategorized Published - 13 July, 2015    By - Dr Clemens
The Relationship of Body Mass Index with the Incidence of Postdural Puncture Headache in Parturients

Published in Anesthesia & Analgesia: May 2015 Authors: Peralta, Feyce MD et al BACKGROUND: Unintentional dural puncture is a known risk after epidural or combined spinal-epidural procedures, occurring in approximately 1% of labor epidural catheters placed in parturients with normal body habitus but may be as high as 4% in morbidly obese parturients. Anecdotal experience […]

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Uncategorized Published - 13 July, 2015    By - Dr Clemens
The RECITE Study: A Canadian Prospective, Multicenter Study of the Incidence and Severity of Residual Neuromuscular Blockade

Published in Anesthesia & Analgesia: April 2015 Authors: Fortier, Louis-Philippe MSc, MD, FRCPC et BACKGROUND: Postoperative residual neuromuscular blockade (NMB), defined as a train-of-four (TOF) ratio of <0.9, is an established risk factor for critical postoperative respiratory events and increased morbidity. At present, little is known about the occurrence of residual NMB in Canada. The […]

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Uncategorized Published - 13 July, 2015    By - Dr Clemens
Topical Gel Promising in Migraine

A fast-acting transdermal gel using a proprietary formulation of the nonsteroidal anti-inflammatory drug (NSAID) ketoprofen (Topofen, Achelios Therapeutics) reduced pain severity in patients with severe migraine with and without aura compared with placebo and had few adverse effects. Results from a phase 2a trial of the gel were presented here at the American Academy of […]

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Uncategorized Published - 10 July, 2015    By - Dr Clemens
Predictors of Delayed Postoperative Respiratory Depression Assessed from Naloxone Administration

Published in Anesthesia & Analgesia May 2015 Authors: Weingarten, Toby N. MD et al BACKGROUND: The aim of this study was to identify patient and procedural characteristics associated with postoperative respiratory depression or sedation requiring naloxone intervention. METHODS: We identified patients who received naloxone to reverse opioid-induced respiratory depression or sedation within 48 hours after […]

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Uncategorized Published - 10 July, 2015    By - Dr Clemens
A Comparison of Differences Between the Systemic Pharmacokinetics of Levobupivacaine and Ropivacaine During Continuous Epidural Infusion: A Prospective, Randomized, Multicenter, Double-Blind Controlled Trial

Anesthesia & Analgesia: May 2015 Authors: Perotti, Luciano MD et al BACKGROUND: Epidural infusion of levobupivacaine and ropivacaine provides adequate postoperative pain management by minimizing side effects related to IV opioids and improving patient outcome. The safety profile of different drugs can be better estimated by comparing their pharmacokinetic profiles than by considering their objective […]

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