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Am J Emerg Med 2015 Sep;33(9):1205-8. Authors: Fathi M et al OBJECTIVES: This randomized clinical trial compares the efficacy and safety of oral oxycodone (an oral opioid) with naproxen (a nonsteroidal anti-inflammatory drug) in acute pain control in patients with soft tissue injury. It also evaluates the need for additional doses of analgesics in the first 24 […]
Read MoreTwo analyses of the safety and efficacy of serotonin (5-HT3) receptor antagonists suggest that the most effective therapies for perioperative vomiting are ondansetron plus droperidol IV and granisetron plus dexamethasone (BMC Med 2015;13:136 and 142). Granisetron plus dexamethasone was also found to be one of the most effective therapies for nausea and for postoperative nausea and […]
Read MoreDose–Response Relationship in Cardiac Surgery: Ottawa, Ontario, Canada—Cardiac anesthesiologists can add acute kidney injury (AKI) to the many deleterious effects of intraoperative hypotension. A retrospective cohort study by a team of Canadian investigators found a relationship between kidney injury and mean arterial pressure (MAP) less than 65 mm Hg, but also uncovered evidence of a […]
Read MoreThe longer a patient is in severe pain during the first 24 hours following surgery, the more likely he or she will still be experiencing some form of chronic postsurgical pain one year later, according to a study presented at Euroanaesthesia 2015. This prospective, observational study (abstract ESAPC1-2), designed to investigate the incidence, characteristics and […]
Read MoreAnesthesia & Analgesia: Sept 2015 Authors: Baeriswyl, Moira MD, et al BACKGROUND: Previous meta-analyses of the transversus abdominis plane (TAP) block have examined a maximum of 12 articles, including fewer than 650 participants, and have not examined the effect of ultrasound-guided techniques specifically. Recently, many trials that use ultrasound approaches to TAP block have been […]
Read MoreCan J Anaesth, 2015 Dec;62(12):1268-1278. Authors: Xiong C et al PURPOSE: Palonosetron, a second-generation 5-hydroxytryptamine 3 receptor antagonist (5-HT3RA), has unique characteristics relative to first-generation 5-HT3RAs such as ondansetron. Nevertheless, it remains unclear if palonosetron is better than ondansetron for the prevention of nausea and vomiting during the first 24 hr after surgery and is thus the […]
Read MoreCan J Anaesth, 2015 Nov;62(11):1169-1178. Authors: Allen M et al PURPOSE: This study aimed to determine if the incidence of recall was equivalent between light and deep sedation for colonoscopy. Secondary analysis included complications, patient clinical recovery, and post-procedure cognitive impairment. METHODS: Two hundred patients undergoing elective outpatient colonoscopy were randomized to light (bispectral index [BIS] 70-80) […]
Read MoreCan J Anaesth, 2015 Dec;62(12):1303-1307 Authors: Thanapaalasgham K et al PURPOSE: Pheochromocytomas (PHEOS) are rare catecholamine-secreting adrenal tumours requiring surgical resection. Preoperative alpha-adrenergic receptor blockade to prevent intraoperative hypertension has traditionally been achieved with phenoxybenzamine. Due to changes in the availability of phenoxybenzamine in Canada, alternate therapies are needed for patients. We report our first experience using […]
Read MoreCapsaicin 8% patch is well-tolerated and provides significant improvements in pain and sleep quality compared with placebo for patients with painful diabetic peripheral neuropathy (PDPN), according to a study presented here at the 51st Annual Meeting of the European Association for the Study of Diabetes (EASD). Capsaicin 8% patch has been used as an analgesic […]
Read MoreThe FDA has granted accelerated approval for idarucizumab (Praxbind) to reverse the anticoagulant effects of dabigatran (Pradaxa) in emergency situations. Idarucizumab, an injectable monoclonal antibody fragment, binds to dabigatran and thereby neutralizes its effect. Approval was based on three trials in which some 280 healthy adults who did not require anticoagulant therapy were given dabigatran […]
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