by Glenn Murphy, MD The Neuromuscular Research Group at Organon Newhouse Scotland (east of Glasgow) had been working on the development of fast-onset, short-acting, nondepolarizing steroidal neuromuscular blocking agents since the 1960s, which led to the development of pancuronium, vecuronium and rocuronium. Shortly after the launch of rocuronium, questions arose about a possible action of […]
Read MoreWhat Would You Expect If You Were the Patient? by Robert K. Stoelting, MD The Anesthesia Patient Safety Foundation (APSF) believes that residual neuromuscular blockade in the postoperative period is a patient safety hazard that could be addressed partially by better and consistent use of our qualitative standard train-of-four (TOF) nerve stimulator monitors, but will […]
Read MoreMORBID OBESITY AND SLEEP APNEA February 2016 – Volume 29 – Issue 1 – p 134–140 AUTHORS: Lam, Karen K. et al Purpose of review: Perioperative opioid-based pain management of patients suffering from obstructive sleep apnea (OSA) may present challenges because of concerns over severe ventilatory compromise. The interaction between intermittent hypoxia, sleep fragmentation, pain, […]
Read MoreAnesthesia & Analgesia: February 2016 – Volume 122 – Issue 2 – p 490–496 AUTHORS: Hörner, Elisabeth MD et al BACKGROUND: The immediate initiation and high quality of basic life support (BLS) are pivotal to improving patient outcome after cardiac arrest. Although cardiorespiratory monitoring could shorten the time to recognize the onset of cardiac arrest, […]
Read MoreFoulds LT et al., Anaesthesia 2016 Feb 5; In this randomized operating-room study, the McGrath Series 5 video laryngoscope led to better glottic views and fewer intubation failures compared with direct laryngoscopy. Previous studies have shown McGrath video laryngoscopy to be superior to direct laryngoscopy when patients are intubated with manual in-line cervical stabilization and an opened […]
Read MoreLee TH., JAMA 2016 Mar 15; Twelve recommendations focus on opioid use for chronic pain not related to cancer or end-of-life care. Background About 20,000 people died from opioid overdoses in 2014; 3% to 4% of the U.S. population receive prescriptions for long-term opioid therapy. The CDC has released what is considered to be the first federal […]
Read MoreAuthors: Ashley C. Brown, PhD et al Anesthesiology published on 2 2016 Background: Quantitative and qualitative differences in the hemostatic systems exist between neonates and adults, including the presence of “fetal” fibrinogen, a qualitatively dysfunctional form of fibrinogen that exists until 1 yr of age. The consequences of “fetal” fibrinogen on clot structure in neonates, particularly in […]
Read MoreAnesthesia & Analgesia: February 29, 2016 AUTHORS: Csorba, Zsofia MD et al BACKGROUND: Although the mechanical status of the lungs affects the shape of the capnogram, the relations between the capnographic parameters and those reflecting the airway and lung tissue mechanics have not been established in mechanically ventilated patients. We, therefore, set out to characterize […]
Read MoreA Prospective Controlled Study in Patients Undergoing Intracranial Surgery Authors: Irene Asouhidou et al BMC Anesthesiol. 2015;15(172) Background: Adequate cerebral perfusion pressure with quick and smooth emergence from anesthesia is a major concern of the neuroanesthesiologist. Anesthesia techniques that minimize anesthetic requirements and their effects may be beneficial. Esmolol, a short acting hyperselective β-adrenergic blocker is effective […]
Read MoreAnesthesia & Analgesia: March 2016 – Volume 122 – Issue 3 – p 758–764 AUTHORS: Anastasian, Zirka H. MD et al BACKGROUND: Factors including ASA physical status, blood loss, and case length have been described as correlating with the decision to delay tracheal extubation after specific surgical procedures. In this retrospective study, we investigated whether […]
Read More