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A Meta-analysis of Randomized Clinical Trials Br J Anaesth. 2015;115(5):656-675. Authors: A. Belletti et al Background: Inotropes and vasopressors are frequently administered to critically ill patients in order to improve haemodynamic function and restore adequate organ perfusion. However, some studies have suggested a possible association between inotrope administration and increased mortality. We therefore performed a meta-analysis of […]
Read MoreUltrasound-guided thoracic paravertebral nerve block (TPVB) is highly effective in controlling pain after breast cancer surgery and lowers the risk of complications, according to a study published in the journal Anesthesia & Analgesia. Previous reports have suggested that performing this nerve block under ultrasound guidance might make the procedure safer. The current study is the […]
Read MoreOpioids may cause short-term improvement in mood, but long-term use imposes risk of new-onset depression, according to a study published online in the Annals of Family Medicine. Long-term opioid use of more than 30 days may lead to changes in neuroanatomy and low testosterone, among other possible biological explanations, according to Jeffrey Scherrer, PhD, Saint […]
Read MoreIncreased use of prescription opioids during pregnancy is likely a contributing factor in the rise in rates of neonatal abstinence syndrome (NAS) in the United States, warns Nora D. Volkow, MD, director of the National Institute on Drug Abuse (NIDA). “The steep increase in the number of opioid prescriptions dispensed in the United States has […]
Read MoreAnesthesiology. 2016 Mar;124(3):598-607 AUTHORS: Lin N et al BACKGROUND: Sedation is commonly used in neurosurgical patients but has been reported to produce transient focal neurologic dysfunction. The authors hypothesized that in patients with frontal-parietal-temporal brain tumors, focal neurologic deficits are unmasked or exacerbated by nonspecific sedation independent of the drug used. METHODS: This was a prospective, […]
Read MorePaediatr Anaesth. 2016 Mar;26(3):315-20 AUTHORS: Hutchins J et al . BACKGROUND: Total pancreatectomy and islet autotransplantation (TPIAT) has been used to treat pediatric patients with chronic pancreatitis. The primary symptom of this disease is extreme poorly controlled pain. This results in significant alterations in the quality of life of the patient. We sought to determine if […]
Read MoreCrit Care Med. 2016 Jan AUTHORS: Welch TP et al OBJECTIVE: To evaluate the clinical effectiveness of bolus-dose fentanyl and midazolam to treat episodic intracranial hypertension in children with severe traumatic brain injury. DESIGN: Retrospective cohort. SETTING: PICU in a university-affiliated children’s hospital level I trauma center. PATIENTS: Thirty-one children aged 0-18 years with severe traumatic […]
Read MoreSurg Today. 2015 Dec 23 AUTHORS: Shibasaki S et al PURPOSE: To clarify the efficacy of postoperative pain management following laparoscopic gastrectomy (LG), we retrospectively compared pain assessments in patients who received fentanyl plus celecoxib with those who received epidural anesthesia. METHODS: From 2011 to 2012, 55 consecutive LG patients at our institution received 48 h of […]
Read MoreSerum levels of the pro-inflammatory cytokine interleukin-6 (IL-6) vary in individuals with lumbar intervertebral disc disease and biochemical profiling of circulating cytokines may assist in refining personalised diagnoses of disc diseases, according to a study published in the journal Arthritis Research and Therapy. Low back pain is caused by multiple triggers that present in similar ways. […]
Read MoreResearchers have found a link between dry eye and chronic pain syndromes — a finding that suggests that a new paradigm is needed for diagnosis and treatment to improve patient outcomes. “Our study indicates that some patients with dry eye have corneal somatosensory pathway dysfunction and would be better described as having neuropathic ocular pain,” […]
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