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Painful diabetic peripheral neuropathy (DPN) can be effectively treated with hepatocyte growth factor gene therapy, according to results of a phase 2 clinical trial presented at the 140th Annual Meeting of the American Neurological Association (ANA). “Diabetic peripheral neuropathy can cause debilitating pain with no effective treatment, and hepatocyte growth factor has potent neurotropic and […]
Read MoreVery low frequency (<2 Hz) stimulation may be more effective at controlling neuropathic pain in patients with spinal-cord injury than higher frequencies (>10 Hz), according to a small, 2-subject study presented on September 28 at the 140th Annual Meeting of the American Neurological Association (ANA). Corneliu Luca MD, PhD, University of Miami Health System, Miami, […]
Read MoreHeadache, 2015 Oct;55(9):1192-208. Authors: Johnson JL et al BACKGROUND: Medication overuse headache (MOH) is a condition bordering between a chronic pain condition and a substance dependence disorder. Activation of immunocompetent glial cells in the central nervous system has been linked to both pathological pain and drug addiction/reward. Preclinically, ibudilast attenuates glial activation and is able to reduce […]
Read MoreJ Arthroplasty, 2015 Sep;30 Authors: Schroer WC et al Liposomal bupivacaine periarticular injection (PAI) offers sustained bupivacaine release after TKA, but few prospective independent studies exist. In this prospective, blinded study, liposomal bupivacaine was randomized against bupivacaine and incorporated into a comprehensive multimodal pain management protocol. 111 primary TKAs were randomized to receive PAI: 58 patients received […]
Read MoreWhat Is Now Available and Efficacious? Authors: J. W. Sear et al Br J Anaesth. 2015;115(3):333-336. Publication, in 2008, of the results of POISE, the largest randomized controlled trial (RCT) of perioperative beta-blockade, confirmed previous studies that had shown beta-blockade to offer cardiac protection in patients with, or at risk for, coronary heart disease.[1] However, this protection […]
Read MoreA Retrospective, Observational Study Authors: Lars Stryhn Bjerregaard et BMC Anesthesiol. 2015;15(91) Background: Despite extensive research, the debate continues as to the optimal way of guiding intraoperative and postoperative fluid therapy. In 2009 we changed our institutional guideline for perioperative fluid therapy in patients undergoing extrapleural pneumonectomy (EPP) and implemented the use of central venous oxygen saturation […]
Read MoreThe United States is facing the worst “man-made epidemic” of opioid abuse in the history of modern medicine, and it is the direct result of poor research and outdated teaching practices, according to a leading pain expert. “There’s been over 200,000 deaths from prescription opioids and many more hundreds of thousands of overdose admissions, and […]
Read MoreAuthors: Aziz MF et al., Anesth Analg 2015 Nov 17; In patients with predicted difficult airways intubated in the operating room, the GlideScope had a higher first-attempt intubation success rate than the C-MAC D-Blade. Video laryngoscopy (VL) improves intubation success in patients with predicted difficult airways primarily by ensuring glottic visualization. While VL with acute-angled devices has been […]
Read MoreAuthors: Karen C. Nanji MD MPH et al Anesthesiology 1 2016, Vol.124, 25-34. Background: The purpose of this study is to assess the rates of perioperative medication errors (MEs) and adverse drug events (ADEs) as percentages of medication administrations, to evaluate their root causes, and to formulate targeted solutions to prevent them. Methods: In this prospective observational study, anesthesia-trained […]
Read MoreThe CDC has proposed 12 recommendations for clinicians prescribing opioids. Among them: When initiating opioid therapy, immediate-release opioids at the lowest effective doses are recommended. Extra precautions should be taken when prescribing at or above 50 morphine milligram equivalents (MME) per day, and doses at or above 90 MME per day generally should be avoided. […]
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