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Evidence for many pain supplements is preliminary or weak, according to some experts. But they’re generally safe—unless you’re taking blood thinners. Interview with Philip Gregory, PharmD, MS, FACN and Marc I. Leavey, MD. Many popular supplements used for pain relief may provide modest benefits for some patients, but are not a magic bullet, according to […]
Read MoreEdited by David G. Fairchild, MD, MPH, and Lorenzo Di Francesco, MD, FACP, FHM Death certificates should allow “medical error” to be listed as a cause, researchers argue in The BMJ. Evaluating estimates published over the past decade, the authors figure that there are roughly 250,000 deaths attributable to medical errors in the U.S. each year. That would rank […]
Read MoreAuthors: Frédérique Hovaguimian, M.D., M.Clin.Res.Meth.et al Anesthesiology published on 5 2016. Background: Blood transfusions are associated with morbidity and mortality. However, restrictive thresholds could harm patients less able to tolerate anemia. Using a context-specific approach (according to patient characteristics and clinical settings), the authors conducted a systematic review to quantify the effects of transfusion strategies. Methods: The authors searched […]
Read MoreAuthors: Sebastian Zaremba, M.D. et al Anesthesiology published on 5 2016. Background: Bariatric surgery patients are vulnerable to sleep-disordered breathing (SDB) early after recovery from surgery and anesthesia. The authors hypothesized that continuous positive airway pressure (CPAP) improves postoperative oxygenation and SDB and mitigates opioid-induced respiratory depression. Methods: In a randomized crossover trial, patients after bariatric surgery received […]
Read MoreAnesthesia & Analgesia: May 2016 – Volume 122 – Issue 5 – p 1603–1613 AUTHORS: Glance, Laurent G. MD et al BACKGROUND: In creating the Merit-Based Incentive Payment System, Congress has mandated pay-for-performance (P4P) for all physicians, including anesthesiologists. There are currently no National Quality Forum–endorsed risk-adjusted outcome metrics for anesthesiologists to use as the […]
Read MoreAuthors: Eun-Ho Lee, M.D. et al Anesthesiology 5 2016, Vol.124, 1001-1011 Background: Hypoalbuminemia may increase the risk of acute kidney injury (AKI). The authors investigated whether the immediate preoperative administration of 20% albumin solution affects the incidence of AKI after off-pump coronary artery bypass surgery. Methods: In this prospective, single-center, randomized, parallel-arm double-blind trial, 220 patients with preoperative […]
Read MoreStudy finds fentanyl transdermal patches are too often prescribed to opioid-naïve and elderly patients, raising their risks of fatal adverse drug events. Interview with Caleb Alexander, MD Fentanyl patches are a highly potent options for cancer and non-cancer pain patients, but are contraindicated in opioid naïve patients. However, new research indicates that physicians may be […]
Read MoreAuthors: Andrew P. Wojtovich, Ph.D. et al Anesthesiology 5 2016, Vol.124, 1065-1076. Background: Anesthetic preconditioning (APC) is a clinically important phenomenon in which volatile anesthetics (VAs) protect tissues such as heart against ischemic injury. The mechanism of APC is thought to involve K+ channels encoded by the Slo gene family, and the authors showed previously that slo-2 is required for APC inCaenorhabditis […]
Read MoreEdited by Susan Sadoughi, MD, and André Sofair, MD, MPH Contrary to its marketing claims, OxyContin’s pain-relieving effects often fall short of 12 hours in many patients, which can lead to a host of other problems, according to an investigation by the Los Angeles Times. OxyContin is approved for 12-hour dosing. Several studies found that the drug’s effects […]
Read MoreAuthors: Roy G. Soto, M.D. et al ASA Monitor 05 2016, Vol.80, 28-29. First off, let’s agree on two basic concepts: capitalism is good and patient safety is good. For decades we have been tempted with a never-ending parade of new, expensive devices and medications that are touted to improve safety and outcomes. Sometimes the acquisition cost […]
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