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Anesthesia & Analgesia: April 13, 2016 AUTHORS: Djafarzadeh, Siamak PhD et al BACKGROUND: Remifentanil interferes with hepatic mitochondrial function. The aim of the present study was to evaluate whether hepatic mitochondrial function is affected by fentanyl, a more widely used opioid than remifentanil. METHODS: Human hepatoma HepG2 cells were exposed to fentanyl or pretreated with […]
Read MoreAnesthesia & Analgesia: April 13, 2016 AUTHORS: Sultan, Pervez MBChB, FRCA et al BACKGROUND: The intrathecal morphine dose achieving optimal analgesia for cesarean delivery while minimizing side effects has not yet been deduced. In this meta-analysis, our objective was to determine whether low- or high-dose intrathecal morphine provides acceptable duration and intensity of analgesia with […]
Read MoreAnesthesia & Analgesia: April 15, 2016 AUTHORS: Takaenoki, Yumiko MD et al BACKGROUND: Under emergent conditions, endotracheal drug administration may be an effective method of delivering emergency drugs. A common technique is to administer these drugs using a nonatomized spray. Atomized drug delivery may be an attractive alternative to nonatomized delivery because atomized particles are […]
Read MoreAnesthesia & Analgesia: June 2016 – Volume 122 – Issue 6 – p 1939–1946 AUTHORS: Traynor, Andrea J. MD et al BACKGROUND: Obstetric Anesthesia Workforce Surveys were conducted in 1981, 1992, and 2001, and the 10-year update was conducted in 2012. Anesthesia providers from US hospitals were surveyed to identify the methods used to provide […]
Read MoreAnesthesia & Analgesia: April 15, 2016 AUTHORS: Zaphiratos, Valerie MD, MSc, FRCPC et al BACKGROUND: Combined spinal-epidural (CSE) analgesia is widely used for delivering labor analgesia. Epidural volume extension (EVE) involves the injection of fluid into the epidural space compressing the dural sac, causing cephalad shift of the cerebral spinal fluid. Our hypothesis was that […]
Read MoreAnesthesia & Analgesia: April 15, 2016 AUTHORS: Bang, Ji-Yeon MD, PhD et al BACKGROUND: Acute kidney injury (AKI) is a primary cause of morbidity and mortality after major abdominal surgery; however, little is known about the effect of anesthetics on the development of AKI after colorectal surgery. The objective of this study was to compare […]
Read MoreAuthors: M Narayanan MB BS MD FRCA FCARCSI EDIC EDRA et al BJA Education. 2016;16(2):72-78. Introduction Patients in intensive care experience distress because of a multitude of factors and a significant proportion is attributable to pain.[1] A vast majority of patients report moderate to severe pain at some point during their intensive care stay. Pain can be […]
Read MoreStudy finds fentanyl transdermal patches are too often prescribed to opioid-naïve and elderly patients, raising their risks of fatal adverse drug events. Interview with Caleb Alexander, MD Fentanyl patches are a highly potent options for cancer and non-cancer pain patients, but are contraindicated in opioid naïve patients. However, new research indicates that physicians may be […]
Read MoreAnesthesia & Analgesia: May 17, 2016 AUTHORS: Zentai, Christian MD et al BACKGROUND: The potential clinical benefits of targeted therapy with coagulation factor concentrates (e.g., fibrinogen) and antifibrinolytic agents (e.g., tranexamic acid [TXA]) for the treatment of trauma-induced coagulopathy are increasingly recognized. We hypothesized that human fibrinogen concentrate (FC) and prothrombin complex concentrate (PCC), administered […]
Read MoreBy now, one would think that all health care workers know the importance of washing their hands, yet a recent study found that staff at outpatient care facilities fail to follow recommendations for hand hygiene 37% of the time, and for safe injection practices 33% of the time, even after having policies in place about […]
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