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Despite the common use of opioid analgesics in the management of chronic pain, no factors have been identified that could predict optimal efficacy of these agents. A study published in the March 2017 issue of Pain showed that psychosocial variables such as depression and anxiety predict the response to morphine analgesia in patients with low back pain […]
Read MoreAnesthesiologists must be key participants in the process of reducing surgical site infections, including ensuring that the correct prophylactic antimicrobial therapy is given 30 to 60 minutes before incision. This is just one of many updated SSI guidelines that were recently published in the Journal of the American College of Surgeons (2017;224:59-74). “Anesthesiologists need to embrace their […]
Read MoreAuthors: Matthieu Biais, M.D., Ph.D. et al Anesthesiology published on June 22, 2017 Background: Mini-fluid challenge of 100 ml colloids is thought to predict the effects of larger amounts of fluid (500 ml) in intensive care units. This study sought to determine whether a low quantity of crystalloid (50 and 100 ml) could predict the effects of […]
Read MoreAuthors: László Asztalos, M.D. et al Anesthesiology published on June 22, 2017 Background: Rocuronium-induced neuromuscular block that spontaneously recovered to a train-of-four count of four can be reversed with sugammadex 0.5 or 1.0 mg/kg. We investigated whether these doses of sugammadex can also reverse vecuronium at a similar level of block. Methods: Sixty-five patients were randomly assigned, and […]
Read MoreAuthors: Karim Asehnoune, M.D., Ph.D. et al Anesthesiology published on June 22, 2017 Background: Patients with brain injury are at high risk of extubation failure. Methods: We conducted a prospective observational cohort study in four intensive care units of three university hospitals. The aim of the study was to create a score that could predict extubation success in […]
Read MoreA weekly injectable depot formulation of buprenorphine may be effective in treating opioid use disorder, according to a small, industry-funded, phase II trial published in JAMA Psychiatry. Currently, sublingual buprenorphine can be diverted and misused. Fifty patients with opioid use disorder who weren’t seeking treatment were randomized to receive two 24- or 32-mg doses of injectable […]
Read MoreAUTHORS: Hoftman, Nir MD et al Anesthesia & Analgesia: March 8, 2017 BACKGROUND: Tidal volume selection during mechanical ventilation utilizes dogmatic formulas that only consider a patient’s predicted body weight (PBW). In this study, we investigate whether forced vital capacity (FVC) (1) correlates better to total lung capacity (TLC) than PBW, (2) predicts low pulmonary compliance, […]
Read MoreAUTHORS: Butwick, Alexander J. MBBS, FRCA, MS et al Anesthesia & Analgesia: March 8, 2017 BACKGROUND: Women who undergo intrapartum caesarean delivery (CD) are at increased risk of postpartum hemorrhage (PPH) compared with those undergoing prelabor CD. To determine whether the presence and strength of the associations between individual risk factors and severe PPH vary among […]
Read MoreDespite becoming a widespread practice, routine use of video laryngoscopy in the ICU is not supported by the evidence. This is the argument made in a recent editorial in JAMA, titled “Video Laryngoscopy in the Intensive Care Unit: Seeing Is Believing, but That Does Not Mean It’s True.” The editorial, by Brian O’Gara, MD, et al (JAMA 2017 […]
Read MoreMany women are prescribed more opioids than needed after C-section, creating a risk for misuse and diversion. Interviews with Brian Bateman, MD, Whitney You, MD, and Nicole Higgins, MD Physicians routinely over-prescribe opioids to patients who undergo Cesarean sections, according to a group of studies published online on June 8, 2017 in the journal Obstetrics & […]
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