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Results from a Phase 3 study of intravenous (IV) tramadol showed that the treatment was beneficial for patients with moderate to moderately severe postoperative pain following bunionectomy surgery. In this multicenter, double-blind, placebo-controlled trial, patients (N=409) were randomized 1:1:1 to a postoperative regimen of IV tramadol 50mg, IV tramadol 25mg, or placebo administered over 15 minutes at […]
Read MoreIntravenous (IV) aminophylline is a safe and effective early treatment for postdural puncture headache, according to a recent study published in Neurology. This randomized, multi-center, placebo-controlled, double-blind study sought to evaluate the efficacy and safety of IV aminophylline for postdural puncture headache. Individuals recruited for the study were treated at 5 centers in China with procedures requiring […]
Read MoreAn article I thought was interesting so I wanted to share. Authors: Likosky DS et al. JAMA Cardiol 2017 Dec 20. Hospitals with high use of early percutaneous coronary intervention had better mortality and higher costs, but costs were balanced by lower 180-day expenditures. Costs in medicine continue to attract considerable attention. A central issue is whether […]
Read MoreAuthors: Estock, Jamie, L., MA et al Journal of Patient Safety: June 2018 – Volume 14 – Issue 2 – p 101–106 Objective: Several factors contribute to medication errors in clinical practice settings, including the design of medication labels. The objective of this study was to quantify the impact of label design on medication safety in a realistic, high-stress clinical […]
Read MoreAUTHORS: Kim, Myoung, Hwa, MD, PhD et al Anesthesia & Analgesia: January 9, 2018 BACKGROUND: Although systemic lidocaine and magnesium have been widely studied as perioperative analgesic adjuvants, they have been rarely evaluated with respect to recovery quality under the same conditions. We compared the quality of recovery 40 (QoR-40) scores of female patients who received intravenous […]
Read MoreAUTHORS: Kim, Do-Hyeong, MD et al Anesthesia & Analgesia: April 2018 – Volume 126 – Issue 4 – p 1353–1361 BACKGROUND: The optimal regional technique for analgesia and improved quality of recovery after video-assisted thoracic surgery (a procedure associated with considerable postoperative pain) has not been established. The main objective in this study was to compare quality […]
Read MoreAUTHORS: Ellenberger, Christoph, MD, MSc et al Anesthesia & Analgesia: April 2018 – Volume 126 – Issue 4 – p 1133–1141 BACKGROUND: Low cardiac output syndrome is a main cause of death after cardiac surgery. We sought to assess the impact of glucose–insulin–potassium (GIK) to enhance myocardial protection in moderate- to high-risk patients undergoing on-pump heart surgery. […]
Read MoreAUTHORS: Sherman, Jodi, D., MD et al Anesthesia & Analgesia: January 9, 2018 BACKGROUND: Traditional medical device procurement criteria include efficacy and safety, ease of use and handling, and procurement costs. However, little information is available about life cycle environmental impacts of the production, use, and disposal of medical devices, or about costs incurred after purchase. Reusable […]
Read MoreAUTHORS: Jerath, Angela, FRCPC, FANZCA, MBBS, BSc et al Anesthesia & Analgesia: January 5, 2018 BACKGROUND: Tranexamic acid (TXA) is a common antifibrinolytic agent used to minimize bleeding in cardiac surgery. Up to 50% cardiac surgical patients have chronic renal dysfunction (CRD). Optimal dosing of TXA in CRD remains poorly investigated. This is important as TXA is […]
Read MoreAUTHORS: Nakamura, Sayaka, MD et al Anesthesia & Analgesia: May 2018 – Volume 126 – Issue 5 – p 1617–1623 BACKGROUND: Inadequate or excess administration of unfractionated heparin for cardiopulmonary bypass (CPB) can cause significant harm. Age-dependent differences in the pharmacodynamics and pharmacokinetics of heparin contribute to increased variability of heparin responsiveness in children. The aims of […]
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