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Isoflurane Disrupts Postsynaptic Density-95 Protein Interactions Causing Neuronal Synapse Loss and Cognitive Impairment in Juvenile Mice via Canonical NO-mediated Protein Kinase-G Signaling

Authors: Swati Agarwal, Ph.D. et al  Anesthesiology August 2022, Vol. 137, 212–231. Background Inhalational anesthetics are known to disrupt PDZ2 domain–mediated protein–protein interactions of the postsynaptic density (PSD)-95 protein. The aim of this study is to investigate the underlying mechanisms in response to early isoflurane exposure on synaptic PSD-95 PDZ2 domain disruption that altered spine densities […]

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Coffee Is Not a Clear Liquid

Authors: Pandit, Sujit K. MD; Loberg, Katherine W. BS; Pandit, Uma A. MD Anesthesia & Analgesia: November 2000 In Response: We greatly appreciate Dr. Sosis’s interest in our paper (1). This also gives us an opportunity to clarify the prevalent ambiguity about types of “clear” liquid that are allowed 2–3 h before elective surgery. Dr. Sosis […]

Ultrasound-Guided Clavipectoral Fascial Plane Block With Intermediate Cervical Plexus Block for Midshaft Clavicular Surgery

AUTHORS: Zhuo, Qian MD et al  Anesthesia & Analgesia: September 2022 – Volume 135 – Issue 3 – p 633-640 BACKGROUND: Regional anesthesia such as interscalene brachial plexus block (ISBPB) with intermediate cervical plexus block (ICPB) is generally a preferred choice for clavicular surgery. However, various studies have shown that these blocks, especially ISBPB, could cause […]

Risk Factors and Consequences of Acute Kidney Injury After Noncardiac Surgery in Children

AUTHORS: Hawkins, Jesse MD et al  Anesthesia & Analgesia: September 2022 – Volume 135 – Issue 3 – p 625-632 BACKGROUND: Postoperative acute kidney injury (AKI) is a serious complication that is associated with prolonged hospital stay, high risk of short-term postsurgical mortality, need for dialysis, and possible progression to chronic kidney disease. To date, very […]