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Uncategorized Published - 22 September, 2022    By - Dr Clemens
Opioid Peptides: A Review of Natural Substances with Opioid Effects

Authors: Geiger J, Bettinger J, Atkinson T. Opioid Peptides: A Review of Natural Substances with Opioid Effects. Pract Pain Manag. 2022 July/August;22(4). This review goes beyond poppies to the world of non-opiate opioid peptides, comparing their physio-chemical and pharmacologic profiles, and discussing their potential for future development and use in pain management. Traditional opioid medications […]

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Uncategorized Published - 21 September, 2022    By - Dr Clemens
Effects of remifentanil on brain responses to noxious stimuli during deep propofol sedation

DG Journal Club AUTHORS: Jesus Pujol, Gerard Martínez-Vilavella, Lluís Gallart, Laura Blanco-Hinojo Br J Anaesth. 2022 Aug 13 BACKGROUND The safety of anaesthesia has improved as a result of better control of anaesthetic depth. However, conventional monitoring does not inform on the nature of nociceptive processes during unconsciousness. A means of inferring the quality of […]

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Uncategorized Published - 21 September, 2022    By - Dr Clemens
Labor epidural analgesia and subsequent risk of offspring autism spectrum disorder and attention-deficit/hyperactivity disorder

DG Journal Club AUTHORS: Tor-Arne Hegvik, Kari Klungsøyr, Ralf Kuja-Halkola, Hanna Remes Am J Obstet Gynecol. 2022 Aug 13 BACKGROUND A recent study has suggested that labor epidural analgesia may be associated with increased rates of offspring autism spectrum disorder (ASD). Subsequent replication attempts have lacked sufficient power to confidently exclude the possibility of a […]

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Uncategorized Published - 21 September, 2022    By - Dr Clemens
Perioperative Neurofilament Light Plasma Concentrations and Cognition before and after Cardiac Surgery

DG Journal Club AUTHORS: Charles H Brown, Alexandria Lewis, Julia Probert, Michelle Parish Anesthesiology. 2022 Aug 19 BACKGROUND Neurofilament light is a marker of neuronal injury and can be measured in blood. Postoperative increases in neurofilament light have been associated with delirium after noncardiac surgery. However, few studies have examined the association of neurofilament light […]

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Uncategorized Published - 21 September, 2022    By - Dr Clemens
Ventilation During Lung Resection and Critical Care

Authors: Spencer P. Walsh, M.D. et al  Anesthesiology August 2022. After the landmark Acute Respiratory Distress Syndrome Network study in 2000, the idea of low tidal volume (VT) ventilation spread through the critical care and anesthesiology communities.  Studies have shown that positive-pressure ventilation contributes to lung inflammation and might predispose general surgery and intensive care unit […]

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