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AUTHORS: Ing, Caleb MD, MS et al Anesthesia & Analgesia: October 2022 – Volume 135 – Issue 4 – p 787-797 BACKGROUND: Some studies have found surgery and anesthesia in children to be associated with neurodevelopmental deficits, but specific reasons for this association have not been fully explored. This study evaluates intraoperative mean arterial pressure (MAP) […]
Read MoreAUTHORS: Togioka, Brandon M. MD et al Anesthesia & Analgesia: October 2022 – Volume 135 – Issue 4 – p 777-786 BACKGROUND: Intraperitoneal chloroprocaine has been used during cesarean delivery to supplement suboptimal neuraxial anesthesia for decades. The short in vitro half-life of chloroprocaine (11–21 seconds) has been cited to support the safety of this approach. […]
Read MoreAUTHORS: Ullmann, Hannah et al Anesthesia & Analgesia: October 2022 – Volume 135 – Issue 4 – p 769-776 BACKGROUND: The value of positive end-expiratory pressure (PEEP) in maintaining oxygenation during ventilation with a laryngeal mask airway (LMA) mask is unclear. To clarify the potential benefit or harm to PEEP application during positive pressure ventilation with […]
Read MoreAUTHORS: Moront, Michael George MD et al Anesthesia & Analgesia: October 2022 – Volume 135 – Issue 4 – p 757-768 BACKGROUND: Antithrombin (AT) activity is reduced during cardiac operations with cardiopulmonary bypass (CPB), which is associated with adverse outcomes. Preoperative AT supplementation, to achieve >58% and <100% AT activity, may potentially reduce postoperative morbidity and […]
Read MoreAUTHORS: Ruscic, Katarina Jennifer MD et al Anesthesia & Analgesia: October 2022 – Volume 135 – Issue 4 – p 673-677 The twenty-first century saw the rise of “systems biology,” an interdisciplinary approach in biomedical research integrating computational modeling, cell biology, proteomics, and genomics to provide an understanding of the larger picture of a tissue or […]
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