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Uncategorized Published - 22 November, 2022    By - Dr Clemens
Reactive Oxygen Species Contributes to Type 2 Diabetic Neuropathic Pain via the Thioredoxin-Interacting Protein-NOD–Like Receptor Protein 3-N-Methyl-D-Aspartic Acid Receptor 2B Pathway

AUTHORS: Wang, Jun-Wu BD et al Anesthesia & Analgesia: October 2022 – Volume 135 – Issue 4 – p 865-876 BACKGROUND: The number of patients with diabetic neuropathic pain (DNP) continues to increase, but available treatments are limited. This study aimed to examine the influence of reactive oxygen species (ROS)-thioredoxin-interacting protein (TXNIP)-NOD–like receptor protein 3 (NLRP3)-N-methyl-D-aspartic […]

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Uncategorized Published - 22 November, 2022    By - Dr Clemens
Open Reimplementation of the BIS Algorithms for Depth of Anesthesia

AUTHOR: Connor, Christopher W. MD, PhD Anesthesia & Analgesia: October 2022 – Volume 135 – Issue 4 – p 855-864 BACKGROUND: BIS (a brand of processed electroencephalogram [EEG] depth-of-anesthesia monitor) scores have become interwoven into clinical anesthesia care and research. Yet, the algorithms used by such monitors remain proprietary. We do not actually know what we […]

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Uncategorized Published - 22 November, 2022    By - Dr Clemens
Outcomes and Disposition of Patients After Case Cancellation on Day of Surgery for Reasons Attributed to Medical or Anesthetic Care

AUTHORS: Tewfik, George L. MD et al  Anesthesia & Analgesia: October 2022 – Volume 135 – Issue 4 – p 845-854 BACKGROUND: Many day-of-surgery cancellations are avoidable, and different strategies are used to prevent these costly adverse events. Despite these past analyses and evaluations of positive interventions, studies have not examined the final disposition of patients […]

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Uncategorized Published - 22 November, 2022    By - Dr Clemens
Dexmedetomidine Diminishes, but Does Not Prevent, Developmental Effects of Sevoflurane in Neonatal Rats

AUTHORS: Yang, Zhengbo MD et al  Anesthesia & Analgesia: October 2022 – Volume 135 – Issue 4 – p 877-887 BACKGROUND: Sevoflurane (SEVO) increases neuronal excitation in neonatal rodent brains through alteration of gamma aminobutyric acid (GABA)(A) receptor signaling and increases corticosterone release. These actions may contribute to mechanisms that initiate the anesthetic’s long-term neuroendocrine and […]

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Uncategorized Published - 21 November, 2022    By - Dr Clemens
Single-Shot Lumbar Erector Spinae Plane Block in Total Hip Replacement

AUTHORS: Chan, Anyon MBChB et al  Anesthesia & Analgesia: October 2022 – Volume 135 – Issue 4 – p 829-836 BACKGROUND: Lumbar erector spinae plane block (ESPB) has been proposed to relieve pain after total hip replacement (THR), but high-quality evidence is scarce. METHODS: This double-blinded (patient and assessor) randomized clinical trial, performed in 2 tertiary […]

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