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Authors: Julia Plakhotnik, B.Sc. et al Anesthesiology December 2022, Vol. 137, 687–703. Background Long-lasting local anesthetic use for perioperative pain control is limited by possible cardiotoxicity (e.g., arrhythmias and contractile depression), potentially leading to cardiac arrest. Off-target cardiac sodium channel blockade is considered the canonical mechanism behind cardiotoxicity; however, it does not fully explain the observed […]
Read MoreAuthors: Andrew Bowdle, M.D., Ph.D., F.A.S.E.; Srdjan Jelacic, M.D., F.A.S.E.; Kelly Michaelsen, M.D., Ph.D Anesthesiology November 2022. To the Editor: We strongly support the implementation of quantitative twitch monitoring to guide neuromuscular blocker administration and to ensure that patients have recovered adequately before extubation, and we applaud the efforts of Weigel et al. and others to do so. Weigel et al. used […]
Read MoreAuthors: Wade A. Weigel, M.D.; Wyndam M. Strodtbeck, M.D. Anesthesiology November 2022. In Reply: We thank Dr. Bowdle et al. for their interest in our article showing how quantitative monitoring can be incorporated into clinical practice. We fear they may have missed the major lesson of this work, however, which was modifying clinician behavior so that the vast majority […]
Read MoreAuthor: Arnoley S. Abcejo, MD ASA Monitor November 2022, Vol. 86, 44. Concussion, or mild traumatic brain injury, results from a physical blow to the head, often synonymous with post-injury concussive symptoms such as headache, cognitive impairment, and sleep disturbance. Our understanding of this disease has grown rapidly over the last two decades. We know that […]
Read MoreAuthors: Toby N. Weingarten, M.D.; Juraj Sprung, M.D., Ph.D. Anesthesiology December 2022, Vol. 137, 735–741. Postoperative respiratory failure secondary to opioid-induced respiratory depression (hereafter termed respiratory depression) can result in permanent morbidity, such as anoxic brain injury, or even death. In many cases, the respiratory failure seems to develop acutely and without warning, often shortly after seemingly reassuring […]
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