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Uncategorized Published - 3 April, 2023    By - Dr Clemens
OCP002, a Mixed Agonist of Opioid and Cannabinoid Receptors, Produces Potent Antinociception With Minimized Side Effects 2023

AUTHORS: Xu, Biao PhD et al  Anesthesia & Analgesia 136(2):p 373-386, February 2023. BACKGROUND: Increasing attention has been attracted to the development of bifunctional compounds to minimize the side effects of opioid analgesics. Pharmacological studies have verified the functional interaction between opioid and cannabinoid systems in pain management, suggesting that coactivation of the opioid and cannabinoid […]

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Uncategorized Published - 31 March, 2023    By - Dr Clemens
Complications and Technical Consideration of Ultrasound-Guided Rectus Sheath Blocks 2023

AUTHORS: Kwon, Hyun-Jung MD et al Anesthesia & Analgesia 136(2):p 365-372, February 2023. BACKGROUND: Although the ultrasound-guided rectus sheath block (RSB) is usually regarded as an easy and safe procedure in clinical settings, there is currently no report on complications incidence. Therefore, the present study investigated complications in a large cohort and described the technical considerations […]

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Uncategorized Published - 31 March, 2023    By - Dr Clemens
Effect of 5% EMLA Cream on Postoperative Sore Throat in Adults Following General Endotracheal Anesthesia 2023

AUTHORS: Murugaiyan, Abishek MD et al  Anesthesia & Analgesia 136(2):p 338-345, February 2023. BACKGROUND: Postoperative sore throat (POST) is a distressing complaint in adults after endotracheal intubation. This study aimed to evaluate the effect of topical application of a eutectic mixture of local anesthetics (EMLA) cream over the endotracheal tube (ETT) cuff on the incidence and […]

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Uncategorized Published - 31 March, 2023    By - Dr Clemens
Effects of Goal-Directed Hemodynamic Therapy Using a Noninvasive Finger-Cuff Monitoring Device on Intraoperative Cerebral Oxygenation and Early Delayed Neurocognitive Recovery in Patients Undergoing Beach Chair Position Shoulder Surgery 2023

AUTHORS: Lee, Chen-Tse MD et al  Anesthesia & Analgesia 136(2):p 355-364, February 2023. BACKGROUND: Perioperative cerebral desaturation events (CDEs) and delayed neurocognitive recovery are common among patients undergoing beach chair position (BCP) shoulder surgery and may be caused by cerebral hypoperfusion. This study tested the hypothesis that the application of goal-directed hemodynamic therapy (GDHT) would attenuate […]

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Uncategorized Published - 31 March, 2023    By - Dr Clemens
Always Assess the Raw Electroencephalogram: Why Automated Burst Suppression Detection May Not Detect All Episodes 2023

AUTHORS: Fleischmann, Antonia MD et al  Anesthesia & Analgesia 136(2):p 346-354, February 2023. BACKGROUND: Electroencephalogram (EEG)-based monitors of anesthesia are used to assess patients’ level of sedation and hypnosis as well as to detect burst suppression during surgery. One of these monitors, the Entropy module, uses an algorithm to calculate the burst suppression ratio (BSR) that […]

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