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Uncategorized Published - 5 April, 2023    By - Dr Clemens
Postoperative pulmonary complications in the ENIGMA II Trial 2023

DG Journal Club AUTHORS: Philip J Peyton, Grace Liskaser, Alexander Ho, Harry Marsh Anesthesiology. 2023 Jan 16 BACKGROUND Nitrous oxide (N2O) promotes absorption atelectasis in poorly ventilated lung segments at high inspired concentrations. The ENIGMA Trial found a higher incidence of postoperative pulmonary complications (PPCs) and wound sepsis with N2O anesthesia in major surgery compared to FIO2 […]

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Uncategorized Published - 4 April, 2023    By - Dr Clemens
The Effect of Intrathecal Morphine on Postoperative Opioid Consumption in Patients Undergoing Abdominal Surgery for Gynecologic Malignancy 2023

AUTHORS: Bang, Yu Jeong MD et al  Anesthesia & Analgesia January 20, 2023. BACKGROUND: Surgery for gynecologic malignancy via midline-laparotomy leads to severe postoperative pain. Adequate pain control while sparing opioid consumption does offer benefits in postoperative complications and recovery. Intrathecal morphine (ITM) provides simple and effective analgesia. In this randomized trial, we compared postoperative […]

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Uncategorized Published - 4 April, 2023    By - Dr Clemens
Appropriate Duration of Perioperative Intravenous Administration of Lidocaine to Provide Satisfactory Analgesia for Adult Patients Undergoing Colorectal Surgery 2023

AUTHORS: Yang, Wei MD et al Anesthesia & Analgesia 136(3):p 494-506, March 2023. BACKGROUND: Perioperative lidocaine infusion has been reported to alleviate pain intensity after colorectal surgery. However, there is no consensus on whether prolonged lidocaine infusion is more effective than short lidocaine infusion. This meta-analysis aimed to determine an appropriate duration of lidocaine infusion in […]

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Uncategorized Published - 4 April, 2023    By - Dr Clemens
Postoperative Risk of Transfusion After Reversal of Residual Neuromuscular Block With Sugammadex Versus Neostigmine 2023

AUTHORS: Schmidt, Marc T et al  Anesthesia & Analgesia 136(4):p 745-752, April 2023. BACKGROUND: Sugammadex and neostigmine are routinely used to reverse residual neuromuscular blocks at the end of surgery. Sugammadex has been linked with prolongation of laboratory coagulation markers, but clinical relevance on postoperative blood loss and transfusions remains unclear. METHODS: In this retrospective, single-center, […]

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Uncategorized Published - 4 April, 2023    By - Dr Clemens
Role of Tumor Necrosis Factor Receptor 1—Reactive Oxygen Species—Caspase 11 Pathway in Neuropathic Pain Mediated by HIV gp120 With Morphine in Rats 2023

AUTHORS: Hayashi, Kentaro MD et al  Anesthesia & Analgesia 136(4):p 789-801, April 2023. | BACKGROUND: Recent clinical research suggests that repeated use of opioid pain medications can increase neuropathic pain in people living with human immunodeficiency virus (HIV; PLWH). Therefore, it is significant to elucidate the exact mechanisms of HIV-related chronic pain. HIV infection and chronic morphine […]

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