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Uncategorized Published - 6 September, 2023    By - Dr Clemens
An Implementation-Effectiveness Study of a Perioperative Delirium Prevention Initiative for Older Adults

AUTHORS: Donovan, Anne L. MD et al BACKGROUND: Postoperative delirium is a common and serious problem for older adults. To better align local practices with delirium prevention consensus guidelines, we implemented a 5-component intervention followed by a quality improvement (QI) project at our institution. METHODS: This hybrid implementation-effectiveness study took place at 2 adult hospitals […]

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Uncategorized Published - 5 September, 2023    By - Dr Clemens
Perioperative changes in neurocognitive and Alzheimer’s disease-related cerebrospinal fluid biomarkers in older patients randomised to isoflurane or propofol for anaesthetic maintenance

Authors: Daniel Villalobos et al British Journals of Anaesthesia June 2023 Background Animal studies have shown that isoflurane and propofol have differential effects on Alzheimer’s disease (AD) pathology and memory, although it is unclear whether this occurs in humans. Methods This was a nested randomised controlled trial within a prospective cohort study; patients age ≥60 […]

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Uncategorized Published - 5 September, 2023    By - Dr Clemens
Brief Preoperative Screening for Frailty and Cognitive Impairment Predicts Delirium after Spine Surgery

Authors: Maria J. Susano, M.D. et al  Anesthesiology December 2020, Vol. 133, 1184–1191. Background Frailty and cognitive impairment are associated with postoperative delirium, but are rarely assessed preoperatively. The study was designed to test the hypothesis that preoperative screening for frailty or cognitive impairment identifies patients at risk for postoperative delirium (primary outcome). Methods In this […]

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Uncategorized Published - 5 September, 2023    By - Dr Clemens
‘It was a great brain, and I miss it’: lay perspectives on postoperative cognitive dysfunction

Authors: Laura Li et al British Journal of Anaesthesia March 1, 2023 Background Postoperative cognitive dysfunction (POCD) is a concern after anaesthesia and surgery, but preoperative discussion of neurocognitive risks with older patients rarely occurs. Anecdotal experiences of POCD are common in the popular media and may inform patient perspectives. However, the degree of alignment […]

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Uncategorized Published - 5 September, 2023    By - Dr Clemens
Contribution of µ opioid receptor-expressing dorsal horn interneurons to neuropathic pain-like behavior in mice

Authors: Yanmei Qi, PhD et al  Anesthesiology August 2023. Background Intersectional genetics have yielded tremendous advances in our understanding of molecularly-identified subpopulations and circuits within the dorsal horn in neuropathic pain. We tested the hypothesis that spinal µ opioid receptor-expressing interneurons (Oprm1-INs) contribute to behavioral hypersensitivity and neuronal sensitization in the spared nerve injury model […]

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