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Authors: Andrew Bowdle, MD, PhD, FASE et al Anesthesiology April 2023. Background The dose of sugammadex recommended by the manufacturer for reversal of rocuronium is 2 mg/kg when the train-of-four count is 2 or more and 4 mg/kg when it is less than 2 but there is a post-tetanic count of at least 1. The purpose of […]
Read MoreСаrdiac Anesthesiologist April 2023 Ketamine is a powerful anesthetic drug that has been used in medical settings for decades. However, its effects on the brain have also led to its use as a recreational drug, leading to controversy surrounding its use. Despite its negative associations, recent research has shown promising potential for the drug in the […]
Read MoreAuthors: Emily P. Mihalko, Ph.D et al Anesthesiology April 2023. Background The use of low-titer group O whole blood is increasing. To reduce wastage, unused units can be converted to packed red blood cells. Supernatant is currently discarded post-conversion; however, it could be a valuable transfusable product. The aim of this study was to evaluate […]
Read MoreAuthors: Kira A Spencer, Ph.D. et al Anesthesiology Newly Published on April 2023. Background. A variety of molecular targets for volatile anesthetics have been suggested including the anesthetic-sensitive K+ leak channel, TREK-1. Knockout of TREK-1 is reported to render mice resistant to volatile anesthetics, making TREK-1 channels compelling targets for anesthetic action. Spinal cord slices from mice, […]
Read MoreAuthors: Andrew S Chang, MS et al Anesthesiology April 2023. Background Suppression of behavioral and physical responses defines the anesthetized state. This is accompanied, in humans, by characteristic changes in EEG patterns. However, these measures reveal little about the neuron or circuit-level physiological action of anesthetics, nor how information is trafficked between neurons. We assess […]
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