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Authors: Andres Zorrilla-Vaca et al AM Surg 2021 Aug;87(8):1189-1195. Introduction: Goal-directed fluid therapy (GDFT) has increasingly been utilized in major surgery as a key component to ensure fluid optimization and adequate tissue perfusion, showing improvements in the rate of morbidity and mortality under conventional care. It is unclear if patients derive similar benefit as part of […]
Read MoreAuthors: Yaras R, Bettinger J Pract Pain Manage. 2023 MayJune:23(2). The following hypothetical case is intended to reflect the changes in the CDC opioid prescribing guidelines (see full background).¹ Below is a step-by-step guide through the management of “legacy” patients on chronic opioid medications. See our separate case on initiating opioid therapy under the new guidelines. Patient’s Medical and Psychiatric […]
Read MoreAuthor: Heidi Splete Practical Pain Management People living with chronic migraine have a new oral option in the form of atogepant tablets. The FDA has approved an expanded indication of atogepant (Qulipta) to include the prevention of chronic migraine in adults, according to a statement from manufacturer AbbVie. Atogepant, an oral calcitonin gene-related peptide (CGRP) receptor […]
Read MoreAuthors: Sergiy M. Nadtochiy, Ph.D. et al Anesthesiology May 2023, Vol. 138, 523–532. Background Heparin anticoagulation has been used successfully for cardiopulmonary bypass (CPB). However, an alternative anticoagulant approach is desirable due to the cases of heparin-induced thrombocytopenia. Dabigatran provides anticoagulation for an in vitro model of simulated CPB. The current analysis tests the hypothesis that dabigatran provides […]
Read MoreAuthors: Niklas Larsson, M.D. et al Anesthesiology May 2023, Vol. 138, 561–563. To the Editor: Lipid mediators derived from arachidonic acid and other precursor polyunsaturated fatty acids, collectively known as oxylipins, are metabolized along different distinct pathways and play important roles in the modulation of inflammation. Blood oxylipin profiles have been shown to correlate with the survival […]
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